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LHX4 gene
Known as:
LIM HOMEOBOX GENE 4
, LIM Homeobox 4 Gene
, LHX4
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This gene plays a role in both transcription and pituitary differentiation.
National Institutes of Health
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Related topics
Related topics
4 relations
Homo sapiens
LIM/Homeobox Protein Lhx4
Transcriptional Regulation
dna binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Contribution of LHX4 Mutations to Pituitary Deficits in a Cohort of 417 Unrelated Patients
Enzo Cohen
,
M. Maghnie
,
+18 authors
M. Legendre
The Journal of clinical endocrinology and…
2017
Corpus ID: 2702020
Context LHX4 encodes a LIM-homeodomain transcription factor that is implicated in early pituitary development. In humans, only 13…
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Review
2011
Review
2011
Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency.
R. Pfäffle
,
J. Klammt
Best practice & research. Clinical endocrinology…
2011
Corpus ID: 31521025
Highly Cited
2010
Highly Cited
2010
Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.
S. Dateki
,
M. Fukami
,
+9 authors
T. Ogata
The Journal of clinical endocrinology and…
2010
Corpus ID: 35352868
CONTEXT Mutations of multiple transcription factor genes involved in pituitary development have been identified in a minor…
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2009
2009
A coding SNP of LHX4 gene is associated with body weight and body length in bovine
G. Ren
,
H. Chen
,
+6 authors
J. Wang
Molecular Biology Reports
2009
Corpus ID: 26056069
Heterozygous mutations in LHX4 are associated with combined pituitary hormone deficiency. In this study, the polymorphism of LHX4…
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Highly Cited
2008
Highly Cited
2008
A novel dysfunctional LHX4 mutation with high phenotypical variability in patients with hypopituitarism.
F. Castinetti
,
A. Saveanu
,
+11 authors
T. Brue
The Journal of clinical endocrinology and…
2008
Corpus ID: 25550733
CONTEXT LHX4 is a LIM homeodomain transcription factor involved in pituitary ontogenesis. Only a few heterozygous LHX4 mutations…
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2007
2007
Hormonal, pituitary magnetic resonance, LHX4 and HESX1 evaluation in patients with hypopituitarism and ectopic posterior pituitary lobe
M. E. Melo
,
S. Marui
,
+4 authors
M. Knoepfelmacher
Clinical endocrinology
2007
Corpus ID: 22077858
Objective LHX4 and HESX1 are important in early stages of pituitary development and their mutations can be associated with an…
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Highly Cited
2005
Highly Cited
2005
Functional relationship between LHX4 and POU1F1 in light of the LHX4 mutation identified in patients with pituitary defects.
K. Machinis
,
S. Amselem
The Journal of clinical endocrinology and…
2005
Corpus ID: 46457857
CONTEXT Pituitary development depends on the actions of a large number of transcription factors. Among them, LHX4 is believed to…
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Highly Cited
2001
Highly Cited
2001
Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4.
K. Machinis
,
J. Pantel
,
+8 authors
S. Amselem
American journal of human genetics
2001
Corpus ID: 3143870
Studies of genetically engineered flies and mice have revealed the role that orthologs of the human LIM homeobox LHX4 have in the…
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Highly Cited
1997
Highly Cited
1997
Multistep control of pituitary organogenesis.
H. Sheng
,
K. Moriyama
,
+4 authors
H. Westphal
Science
1997
Corpus ID: 46661122
Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch…
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1997
1997
Lhx4, a LIM homeobox gene.
T. Yamashita
,
K. Moriyama
,
H. Sheng
,
H. Westphal
Genomics
1997
Corpus ID: 19331349
LIM homeobox genes are well conserved in evolution and play important roles as transcriptional regulators of embryonic…
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