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Mutations of multiple transcription factor genes involved in pituitary development have been identified in a minor… Expand Heterozygous mutations in LHX4 are associated with combined pituitary hormone deficiency. In this study, the polymorphism of LHX4… Expand CONTEXT
LHX4 is a LIM homeodomain transcription factor involved in pituitary ontogenesis. Only a few heterozygous LHX4 mutations… Expand Objective LHX4 and HESX1 are important in early stages of pituitary development and their mutations can be associated with an… Expand CONTEXT
Pituitary development depends on the actions of a large number of transcription factors. Among them, LHX4 is believed to… Expand The pathophysiology of combined pituitary hormone deficiency (CPHD) is just beginning to be elucidated, with mutations in genes… Expand LHX4 gene is a member of the LIM-homeobox gene family and plays a critical role in the development of motor neurons. We have… Expand Studies of genetically engineered flies and mice have revealed the role that orthologs of the human LIM homeobox LHX4 have in the… Expand Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch… Expand LIM homeobox genes are well conserved in evolution and play important roles as transcriptional regulators of embryonic… Expand