FAQ

LHX4 gene

Known as: LIM HOMEOBOX GENE 4, LIM Homeobox 4 Gene, LHX4 
This gene plays a role in both transcription and pituitary differentiation.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
02419972017

Related topics

Related topics

4 relations
Homo sapiensLIM/Homeobox Protein Lhx4Transcriptional Regulationdna binding

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
LHX4 gene
dna binding
Homo sapiens
Transcriptional Regulation
LIM/Homeobox Protein Lhx4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.
CONTEXT Mutations of multiple transcription factor genes involved in pituitary development have been identified in a minor… (More)
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2010
2010
A novel mutation (V101A) of the LHX4 gene in a Japanese patient with combined pituitary hormone deficiency.
OBJECTIVE LHX4, a LIM-homeodomain transcription factor, is required for development of the pituitary and nervous system. Several… (More)
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2009
2009
A coding SNP of LHX4 gene is associated with body weight and body length in bovine
Heterozygous mutations in LHX4 are associated with combined pituitary hormone deficiency. In this study, the polymorphism of LHX4… (More)
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2008
2008
Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies.
CONTEXT The LHX4 LIM-homeodomain transcription factor has essential roles in pituitary gland and nervous system development… (More)
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2008
2008
A novel dysfunctional LHX4 mutation with high phenotypical variability in patients with hypopituitarism.
CONTEXT LHX4 is a LIM homeodomain transcription factor involved in pituitary ontogenesis. Only a few heterozygous LHX4 mutations… (More)
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2007
2007
A novel missense mutation (P366T) of the LHX4 gene causes severe combined pituitary hormone deficiency with pituitary hypoplasia, ectopic posterior lobe and a poorly developed sella turcica.
LIM homeodomain transcription factors regulate many aspects of development in multicellular organisms. LHX4/Lhx4 is a protein… (More)
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2005
2005
Functional relationship between LHX4 and POU1F1 in light of the LHX4 mutation identified in patients with pituitary defects.
CONTEXT Pituitary development depends on the actions of a large number of transcription factors. Among them, LHX4 is believed to… (More)
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Highly Cited
2001
Highly Cited
2001
Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4.
Studies of genetically engineered flies and mice have revealed the role that orthologs of the human LIM homeobox LHX4 have in the… (More)
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Highly Cited
1997
Highly Cited
1997
Multistep control of pituitary organogenesis.
Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch… (More)
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1997
1997
Lhx4, a LIM homeobox gene.
LIM homeobox genes are well conserved in evolution and play important roles as transcriptional regulators of embryonic… (More)
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