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LHX4 gene

Known as: LIM HOMEOBOX GENE 4, LIM Homeobox 4 Gene, LHX4 
This gene plays a role in both transcription and pituitary differentiation.
National Institutes of Health

Related topics

Related topics

4 relations
Homo sapiensLIM/Homeobox Protein Lhx4Transcriptional Regulationdna binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.
CONTEXT Mutations of multiple transcription factor genes involved in pituitary development have been identified in a minor… Expand
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2009
2009
A coding SNP of LHX4 gene is associated with body weight and body length in bovine
Heterozygous mutations in LHX4 are associated with combined pituitary hormone deficiency. In this study, the polymorphism of LHX4… Expand
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Highly Cited
2008
Highly Cited
2008
A novel dysfunctional LHX4 mutation with high phenotypical variability in patients with hypopituitarism.
CONTEXT LHX4 is a LIM homeodomain transcription factor involved in pituitary ontogenesis. Only a few heterozygous LHX4 mutations… Expand
2007
2007
Hormonal, pituitary magnetic resonance, LHX4 and HESX1 evaluation in patients with hypopituitarism and ectopic posterior pituitary lobe
Objective  LHX4 and HESX1 are important in early stages of pituitary development and their mutations can be associated with an… Expand
Highly Cited
2005
Highly Cited
2005
Functional relationship between LHX4 and POU1F1 in light of the LHX4 mutation identified in patients with pituitary defects.
CONTEXT Pituitary development depends on the actions of a large number of transcription factors. Among them, LHX4 is believed to… Expand
Highly Cited
2004
Highly Cited
2004
Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.
The pathophysiology of combined pituitary hormone deficiency (CPHD) is just beginning to be elucidated, with mutations in genes… Expand
2002
2002
cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4
LHX4 gene is a member of the LIM-homeobox gene family and plays a critical role in the development of motor neurons. We have… Expand
Highly Cited
2001
Highly Cited
2001
Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4.
Studies of genetically engineered flies and mice have revealed the role that orthologs of the human LIM homeobox LHX4 have in the… Expand
Highly Cited
1997
Highly Cited
1997
Multistep control of pituitary organogenesis.
Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch… Expand
1997
1997
Lhx4, a LIM homeobox gene.
LIM homeobox genes are well conserved in evolution and play important roles as transcriptional regulators of embryonic… Expand
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