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LHX3 gene

Known as: LIM homeobox 3, LIM3, LHX3 
This gene encodes a transcription factor that plays a role in both pituitary development and motor neuron specification.
National Institutes of Health

Related topics

Related topics

6 relations
Cell Differentiation processHomo sapiensLhx3 proteinPattern Formation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
The Forkhead Transcription Factor, Foxd1, Is Necessary for Pituitary Luteinizing Hormone Expression in Mice
The pituitary gland regulates numerous physiological functions including growth, reproduction, temperature and metabolic… 
Review
2009
Review
2009
LHX3 and LHX4 transcription factors in pituitary development and disease.
The LHX3 and LHX4 LIM-homeodomain proteins are regulatory transcription factors that play overlapping but distinct functions… 
2007
2007
Transgenic mice expressing LHX3 transcription factor isoforms in the pituitary: Effects on the gonadotrope axis and sex‐specific reproductive disease
The LHX3 transcription factor plays critical roles in pituitary and nervous system development. Mutations in the human LHX3 gene… 
2006
2006
The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter.
The GnRH receptor (GnRH-R) plays a central role in mammalian reproductive function throughout adulthood. It also appears as an… 
2002
2002
Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility.
2002
2002
A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4
Chromosome 1q21-25 is one of the hotspots of chromosomal abnormalities including translocations and duplications in hematological… 
Review
2002
Review
2002
Genetic defects in the development and function of the anterior pituitary gland
Genetic defects affecting the hypothalamic-pituitary-target organ axes can cause a variety of diseases involving restricted or… 
1999
1999
Characterization of the porcine Lhx3/LIM-3/P-Lim LIM homeodomain transcription factor
1999
1999
Characterization of paxillin LIM domain‐associated serine threonine kinases: Activation by angiotensin II in vascular smooth muscle cells
Recently we reported a novel means of regulating LIM domain protein function. Paxillin LIM zinc‐finger phosphorylation in… 
Highly Cited
1998
Highly Cited
1998
Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin.
We have previously shown that the LIM domains of paxillin operate as the focal adhesion (FA)-targeting motif of this protein. In… 
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