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LG 100268

Known as: LG-100268, LG100268 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2016
024619952016

Related topics

Related topics

2 relations

Broader (2)

Nicotinic AcidsTetrahydronaphthalenes

Related mentions per year

Related mentions per year

1938-2018
19401960198020002020
LG 100268
Nicotinic Acids
Tetrahydronaphthalenes

Papers overview

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2007
2007
The Rexinoid LG100268 prevents the development of preinvasive and invasive estrogen receptor negative tumors in MMTV-erbB2 mice.
PURPOSE To test whether a novel rexinoid, LG100268, prevents the development of preinvasive and invasive estrogen receptor… (More)
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2002
2002
Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268.
The selective estrogen receptor modulator arzoxifene and the rexinoid LG 100268 were active not only as single agents for… (More)
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Highly Cited
2002
Highly Cited
2002
Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia.
It has been shown that the novel synthetic triterpenoid CDDO inhibits proliferation and induces differentiation and apoptosis in… (More)
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2002
2002
The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.
Ligands that specifically target retinoid-X receptors (RXRs) are emerging as potentially powerful therapies for cancer, diabetes… (More)
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2000
2000
Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells.
Ovarian granulosa cells synthesize estrogens from androgens, which are catalyzed by aromatase cytochrome P450 (P450arom… (More)
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2000
2000
HIV protease inhibitors stimulate hepatic triglyceride synthesis.
Hyperlipidemia may complicate the use of HIV protease inhibitors (PIs) in AIDS therapy. To determine the cause of hyperlipidemia… (More)
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Highly Cited
1999
Highly Cited
1999
Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death.
The present study examined the expression and role of the thiazolidinedione (TZD)-activated transcription factor, peroxisome… (More)
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1999
1999
The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction
Aims/hypothesis. Although retinoid X receptor (RXR) and peroxisome proliferator activated receptor-γ (PPARγ) agonists have… (More)
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Highly Cited
1995
Highly Cited
1995
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.
Structural modifications of the retinoid X receptor (RXR) selective compound 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2… (More)
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1995
1995
9-cis retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of fas ligand and requires retinoic acid receptor and retinoid X receptor activation.
T-cell hybridomas, thymocytes, and T cells can be induced to undergo apoptotic cell death by activation through the T-cell… (More)
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