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LG 100268

Known as: LG-100268, LG100268 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Nicotinic AcidsTetrahydronaphthalenes

Papers overview

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Highly Cited
2004
Highly Cited
2004
Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias.
The peroxisome proliferator-activated receptor gamma (PPAR gamma) is a member of the nuclear receptor family that forms… Expand
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2002
2002
The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12.
Ligands that specifically target retinoid-X receptors (RXRs) are emerging as potentially powerful therapies for cancer, diabetes… Expand
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2001
2001
Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity.
Hypertriglyceridemia is a frequent complication accompanying the treatment of patients with either retinoids or rexinoids… Expand
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2001
2001
Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.
Both retinoid X receptor (RXR)-selective agonists (rexinoids) and thiazolidinediones (TZDs), PPAR (peroxisome proliferator… Expand
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2001
2001
Combined treatment with specific ligands for PPARγ:RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cells
Our previous study demonstrated that PPARgamma specific ligand troglitazone (TGZ) or RXR specific ligand LG100268 (LG) alone… Expand
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Highly Cited
2000
Highly Cited
2000
HIV protease inhibitors stimulate hepatic triglyceride synthesis.
Hyperlipidemia may complicate the use of HIV protease inhibitors (PIs) in AIDS therapy. To determine the cause of hyperlipidemia… Expand
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Highly Cited
2000
Highly Cited
2000
Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells.
Ovarian granulosa cells synthesize estrogens from androgens, which are catalyzed by aromatase cytochrome P450 (P450arom… Expand
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Highly Cited
1999
Highly Cited
1999
Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death.
The present study examined the expression and role of the thiazolidinedione (TZD)-activated transcription factor, peroxisome… Expand
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1999
1999
Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids.
Peroxisome proliferator activated receptor gamma (PPARgamma) plays a central role in the process of adipocyte differentiation… Expand
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1997
1997
Retinoid X receptor (RXR) ligands activate the human 25-hydroxyvitamin D3-24-hydroxylase promoter via RXR heterodimer binding to two vitamin D-responsive elements and elicit additive effects with 1…
We have previously shown that RNA levels of kidney 25-hydroxyvitamin D3-24-hydroxylase (24(OH)ase), a key metabolic enzyme for 1… Expand
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