Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

LE 135

Known as: LE-135, LE135 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Dibenzazepines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β.
The accumulation of plaques of β-amyloid (Aβ) peptides, a hallmark of Alzheimer's disease, results from the sequential cleavage… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2014
2014
All-trans retinoic acid attenuates experimental colitis through inhibition of NF-κB signaling.
Inflammatory bowel disease (IBD) is characterized by excessive innate immune cell activation, which is responsible for tissue… Expand
Is this relevant?
2013
2013
Retinoic acid receptor beta mediates all-trans retinoic acid facilitation of mesenchymal stem cells neuronal differentiation.
All-trans retinoic acid plays an important role in nervous system development. However, the effects of all-trans retinoic acid on… Expand
Is this relevant?
2010
2010
All-trans retinoic acid ameliorates trinitrobenzene sulfonic acid-induced colitis by shifting Th1 to Th2 profile.
Inflammatory bowel disease is characterized with uncontrolled immune response in inflamed mucosa, with dominance of Th1 cells… Expand
Is this relevant?
Highly Cited
2009
Highly Cited
2009
All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis.
IBD is characterized by uncontrolled immune responses in inflamed mucosa, with dominance of IL-17-producing cells and deficiency… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2005
2005
Retinoic acid-dependent attraction of adult spinal cord axons towards regenerating newt limb blastemas in vitro.
Adult urodele amphibians possess the unique ability to regenerate amputated limbs and to re-innervate these regenerating… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Retinoic acid imprints gut-homing specificity on T cells.
For a preferential homing of T cells to the gut, expression of the integrin alpha4beta7 and the chemokine receptor CCR9 is… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.
The vitamin A metabolite, retinoic acid (RA), affects Th1 and Th2 development. The effect is partly exerted through the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1999
1999
Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer…
Four candidate retinoid antagonists (LE135, LE511, LE540, and LE550) were designed on the basis of the ligand superfamily concept… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
In human HL-60 promyelocytic leukemia cells, diazepinylbenzoic acid derivatives can exhibit either antagonistic or synergistic… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE