LE 135

The accumulation of plaques of β‐amyloid (Aβ) peptides, a hallmark of Alzheimer's disease, results from the sequential cleavage… Expand

Inflammatory bowel disease (IBD) is characterized by excessive innate immune cell activation, which is responsible for tissue… Expand

All-trans retinoic acid plays an important role in nervous system development. However, the effects of all-trans retinoic acid on… Expand

Retinoic acid receptor beta 2 (RARβ2) has been proposed as an important receptor mediating retinoid‐induced axonal growth and… Expand

IBD is characterized by uncontrolled immune responses in inflamed mucosa, with dominance of IL‐17‐producing cells and deficiency… Expand

Adult urodele amphibians possess the unique ability to regenerate amputated limbs and to re-innervate these regenerating… Expand

For a preferential homing of T cells to the gut, expression of the integrin alpha4beta7 and the chemokine receptor CCR9 is… Expand

The vitamin A metabolite, retinoic acid (RA), affects Th1 and Th2 development. The effect is partly exerted through the… Expand

Four candidate retinoid antagonists (LE135, LE511, LE540, and LE550) were designed on the basis of the ligand superfamily concept… Expand

In human HL-60 promyelocytic leukemia cells, diazepinylbenzoic acid derivatives can exhibit either antagonistic or synergistic… Expand