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LE 135

Known as: LE-135, LE135 
National Institutes of Health

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1 relation

Broader (1)

Dibenzazepines

Papers overview

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Highly Cited
2014
Highly Cited
2014
Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β
The accumulation of plaques of β‐amyloid (Aβ) peptides, a hallmark of Alzheimer's disease, results from the sequential cleavage… 
Highly Cited
2014
Highly Cited
2014
All-trans retinoic acid attenuates experimental colitis through inhibition of NF-κB signaling.
2011
2011
Cloning and expression of a retinoic acid receptor β2 subtype from the adult newt: Evidence for an early role in tail and caudal spinal cord regeneration
Retinoic acid receptor beta 2 (RARβ2) has been proposed as an important receptor mediating retinoid‐induced axonal growth and… 
Highly Cited
2009
Highly Cited
2009
All‐trans retinoic acid down‐regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis
IBD is characterized by uncontrolled immune responses in inflamed mucosa, with dominance of IL‐17‐producing cells and deficiency… 
2005
2005
Retinoic acid-dependent attraction of adult spinal cord axons towards regenerating newt limb blastemas in vitro.
Highly Cited
2004
Highly Cited
2004
Retinoic acid imprints gut-homing specificity on T cells.
Highly Cited
2003
Highly Cited
2003
Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors.
The vitamin A metabolite, retinoic acid (RA), affects Th1 and Th2 development. The effect is partly exerted through the… 
Review
2002
Review
2002
Novel synthetic retinoids and separation of the pleiotropic retinoidal activities.
  • H. Kagechika
  • Current medicinal chemistry
  • 2002
  • Corpus ID: 43779621
Retinoids, all-trans-retinoic acid (1a) and its analogs, act as specific modulators of cellular differentiation and proliferation… 
Highly Cited
1999
Highly Cited
1999
Identification of a Novel Class of Retinoic Acid Receptor β-Selective Retinoid Antagonists and Their Inhibitory Effects on AP-1 Activity and Retinoic Acid-induced Apoptosis in Human Breast Cancer…
Four candidate retinoid antagonists (LE135, LE511, LE540, and LE550) were designed on the basis of the ligand superfamily concept… 
Highly Cited
1997
Highly Cited
1997
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
In human HL-60 promyelocytic leukemia cells, diazepinylbenzoic acid derivatives can exhibit either antagonistic or synergistic… 
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