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LE 135

Known as: LE-135, LE135 
National Institutes of Health

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1 relation

Broader (1)

Dibenzazepines

Papers overview

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2014
2014
Regulating Chondrogenesis of Human Mesenchymal Stromal Cells with a Retinoic Acid Receptor-Beta Inhibitor: Differential Sensitivity of Chondral Versus Osteochondral Development
Aim: Main objective was to investigate whether the synthetic retinoic acid receptor (RAR)-β antagonist LE135 is able to drive in… 
2013
2013
Retinoic acid receptor beta mediates all-trans retinoic acid facilitation of mesenchymal stem cells neuronal differentiation.
2013
2013
730 Cyclic GMP Kinase II (CKII) Inhibits NHE3 by Affecting Trafficking via Phosphorylating NHE3 At Three Sites: Identification of a Multifunctional Phosphorylation Site
2012
2012
Intracrine prostaglandin E(2) signalling regulates hypoxia-inducible factor-1α expression through retinoic acid receptor-β.
2011
2011
Chondrogenic effects of exogenous retinoic acid or a retinoic acid receptor antagonist (LE135) on equine chondrocytes and bone marrow-derived mesenchymal stem cells in monolayer culture.
OBJECTIVE To determine effects of various concentrations of retinoic acid (RA) or a synthetic RA receptor antagonist (LE135) on… 
2011
2011
The role of retinoic acid receptor inhibitor LE135 on the osteochondral differentiation of human bone marrow mesenchymal stem cells
The present study aimed to investigate the role of a retinoic acid receptor‐β (RARβ) inhibitor LE135 on TGF‐β induced… 
2010
2010
All-trans retinoic acid ameliorates trinitrobenzene sulfonic acid-induced colitis by shifting Th1 to Th2 profile.
Inflammatory bowel disease is characterized with uncontrolled immune response in inflamed mucosa, with dominance of Th1 cells… 
2009
2009
All-trans Retinoic Acid Down-regulates Inflammatory Responses by Shifting the Treg/th17 Profile in Human Ulcerative and Murine Colitis
IBD is characterized by uncontrolled immune responses in inflamed mucosa, with dominance of IL-17-producing cells and deficiency… 
1998
1998
Effect of retinoic acid on morphological changes of human pancreatic cancer cells on collagen gels: a possible association with the metastatic potentials.
Pancreatic carcinoma is an invasive and metastasizing type of malignancy. We established six pancreatic cancer cell lines from… 
Review
1996
Review
1996
[Retinoid antagonists].
Retinoids, retinoic acid and its bioisosters, regulate many biological functions such as cell differentiation, proliferation and… 
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