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LDK378

Known as: LDK 378 
National Institutes of Health

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Broader (1)

ceritinib

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Synthesis and anti-tumor efficacy of novel 2, 4-diarylaminopyrimidine derivatives bearing N-(3-pyridinylmethyl) urea moiety as anaplastic lymphoma kinase inhibitors.
Review
2019
Review
2019
Safety and Tolerability of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer
The chimeric protein echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase, resulting from the… 
2017
2017
Rhabdomyosarcoma cells are susceptible to cell death by LDK378 alone or in combination with sorafenib independently of anaplastic lymphoma kinase status
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that is often overexpressed in rhabdomyosarcoma (RMS). However… 
2016
2016
Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors.
2016
2016
Crizotinib Primary Resistance Overcome by Ceritinib in a Patient with ALK-Rearranged Non-Small Cell Lung Cancer
We report on the case of a patient affected by advanced non-small cell lung cancer (NSCLC) harboring an anaplastic lymphoma… 
2015
2015
Successful implementation of a novel trial model: The Signature program.
106 Background: Here we describe 8 ongoing single agent clinical protocols under Novartis’ “Signature” program involving… 
2014
2014
BM-32CERITINIB (LDK378) FOR TREATMENT OF PATIENTS WITH ALK-REARRANGED (ALK+) NON-SMALL CELL LUNG CANCER (NSCLC) AND BRAIN METASTASES (BM) IN THE ASCEND-1 TRIAL
BACKGROUND: Ceritinib is an ALK inhibitor (ALKi) recently approved for patients with ALK+ advanced NSCLC. Efficacy and safety… 
2012
2012
First-in-human phase I study of the ALK inhibitor LDK378 in advanced solid tumors.
3007 Background: LDK378 is a novel, potent and selective small molecule anaplastic lymphoma kinase (ALK) inhibitor (IC50 0.00015… 
2012
2012
Istorinės LDK teisės aidas moderniojoje Lietuvos teisėje
Upon reinstitution of the Lithuanian state in the beginning of the twentieth century, some people reflected back to the times… 
2011
2011
Pendekatan Kaunseling mengikut Pendekatan Psikologi Kognitif Ad-Din dalam Modul Latihan Dalam Kumpulan: Kerja Lapangan bersama dengan Anak Yatim
Kursus Tamadun Islam dan Tamadun Asia (TITAS) merupakan kursus generik yang perlu diambil oleh semua pelajar di universiti tanpa… 
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