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LCL161

Known as: Smac Mimetic LCL161 
An orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family… Expand
National Institutes of Health

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2016
2016
BackgroundLCL161, a novel Smac mimetic, is known to have anti-tumor activity and improve chemosensitivity in various cancers… Expand
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Highly Cited
2016
Highly Cited
2016
The cellular inhibitors of apoptosis (cIAP) 1 and 2 are amplified in about 3% of cancers and have been identified in multiple… Expand
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Highly Cited
2014
Highly Cited
2014
PURPOSE LCL161 antagonizes the function of inhibitor of apoptosis proteins (IAPs), thereby promoting cancer cell death. This… Expand
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2014
2014
Inhibitor of Apoptosis Proteins (IAPs) are key regulators of apoptosis in hepatocellular carcinoma (HCC) and their expression is… Expand
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Review
2013
Review
2013
Inhibitor of apoptosis (IAP) proteins play a critical role in the control of survival and cell death by regulating key signaling… Expand
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2013
2013
Currently, unresectable esophageal squamous cell carcinoma (ESCC) is primarily treated by chemoradiotherapy. However, the outcome… Expand
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Highly Cited
2012
Highly Cited
2012
LCL161, a SMAC mimetic, was tested against the PPTP in vitro panel (1.0 nM to 10.0 µM) and the PPTP in vivo panels (30 or 75 mg… Expand
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2012
2012
In this study, we investigated the effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma (HCC). LCL161 showed… Expand
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Highly Cited
2010
Highly Cited
2010
Drug resistance is a growing concern with clinical use of tyrosine kinase inhibitors. Utilizing in vitro models of intrinsic drug… Expand
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2010
2010
Introduction: LCL161 is a potent small molecule mimetic of the Smac mitochondrial protein. Like Smac, it binds to inhibitor of… Expand
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