LCL161

Known as: Smac Mimetic LCL161 
An orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2018
051020102018

Papers overview

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2016
2016
Disturbed redox homeostasis with both elevated reactive oxygen species (ROS) levels and antioxidant defense mechanisms has been… (More)
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2016
2016
BACKGROUND LCL161, a novel Smac mimetic, is known to have anti-tumor activity and improve chemosensitivity in various cancers… (More)
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2014
2014
PURPOSE LCL161 antagonizes the function of inhibitor of apoptosis proteins (IAPs), thereby promoting cancer cell death. This… (More)
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2014
2014
Inhibitor of Apoptosis Proteins (IAPs) are key regulators of apoptosis in hepatocellular carcinoma (HCC) and their expression is… (More)
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2013
2013
Currently, unresectable esophageal squamous cell carcinoma (ESCC) is primarily treated by chemoradiotherapy. However, the outcome… (More)
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2013
2013
Past efforts to pharmacologically disrupt the development and growth of renal cystic lesions focused primarily on normalizing the… (More)
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2013
2013
Tumor cells can evade programmed cell death via up-regulation of inhibitor of apoptosis proteins (IAPs). LCL161 is a small… (More)
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2012
2012
LCL161, a SMAC mimetic, was tested against the PPTP in vitro panel (1.0 nM to 10.0 µM) and the PPTP in vivo panels (30 or 75 mg… (More)
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2012
2012
In this study, we investigated the effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma (HCC). LCL161 showed… (More)
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2010
2010
Drug resistance is a growing concern with clinical use of tyrosine kinase inhibitors. Utilizing in vitro models of intrinsic drug… (More)
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