LB42908

Known as: LB 42908

National Institutes of Health

Papers overview

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2006

2006

The farnesyltransferase inhibitor, LB42708, inhibits growth and induces apoptosis irreversibly in H-ras and K-ras-transformed rat intestinal epithelial cells.

2006

2006

Confirmation of a linkage between H‐Ras and MMP‐13 expression as well as MMP‐9 by chemical genomic approach

As farnesylation of the Ras protein by farnesyl transferase is a critical step for the Ras functional activity, the farnesyl…

2005

2005

Enhancement of interleukin-12 gene-based tumor immunotherapy by the reduced secretion of p40 subunit and the combination with farnesyltransferase inhibitor.

Interleukin-12 (IL-12) gene was shown to produce both IL-12 and p40 subunit. The excess production of the p40 subunit as a…