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LARP6 gene

Known as: La ribonucleoprotein domain family member 6, LARP6, ACHERON 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2017
02420092017

Papers overview

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2016
2016
Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen.
La ribonucleoprotein domain family, member 6 (LARP6) is the RNA binding protein, which regulates translation of collagen mRNAs… (More)
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2015
2015
Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module
The La-related proteins (LARPs) form a diverse group of RNA-binding proteins characterized by the possession of a composite RNA… (More)
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2014
2014
Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA.
Collagen content in atherosclerotic plaque is a hallmark of plaque stability. Our earlier studies showed that insulin-like growth… (More)
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2014
2014
Role of LARP6 and Nonmuscle Myosin in Partitioning of Collagen mRNAs to the ER Membrane
Type I collagen is extracellular matrix protein composed of two α1(I) and one α2(I) polypeptides that fold into triple helix… (More)
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2014
2014
Characterization of binding of LARP6 to the 5’ stem-loop of collagen mRNAs: Implications for synthesis of type I collagen
Type I collagen is composed of 2 polypeptides, α1(I) and α2(I), which fold into triple helix. Collagen α1(I) and α2(I) mRNAs have… (More)
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2013
2013
Tacrolimus (FK506) Prevents Early Stages of Ethanol Induced Hepatic Fibrosis by Targeting LARP6 Dependent Mechanism of Collagen Synthesis
Tacrolimus (FK506) is a widely used immunosuppressive drug. Its effects on hepatic fibrosis have been controversial and… (More)
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2012
2012
A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs.
Type I collagen is composed of two α1(I) polypeptides and one α2(I) polypeptide and is the most abundant protein in the human… (More)
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2011
2011
Progress towards discovery of antifibrotic drugs targeting synthesis of type I collagen.
Type I collagen is the most abundant protein in human body. Fibrosis is characterized by excessive synthesis of type I collagen… (More)
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2011
2011
A novel role of vimentin filaments: binding and stabilization of collagen mRNAs.
The stem-loop in the 5' untranslated region (UTR) of collagen α1(I) and α2(I) mRNAs (5'SL) is the key element regulating their… (More)
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2010
2010
Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen.
Type I collagen is the most abundant protein in the human body, produced by folding of two alpha1(I) polypeptides and one alpha2… (More)
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