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L19-IL2 Monoclonal Antibody-Cytokine Fusion Protein

Known as: L19-IL2 
An immunoconjugate consisting of the recombinant form of the cytokine interleukin-2 (IL-2) fused to a human single-chain Fv (scFv) antibody fragment… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Abstract The intratumoral injection of cytokines, in particular IL2, has shown promise for cutaneous melanoma patients with… Expand
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Highly Cited
2014
Highly Cited
2014
Purpose: Radiotherapy modifies the tumor microenvironment and causes the release of tumor antigens, which can enhance the effect… Expand
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Highly Cited
2014
Highly Cited
2014
Weide and colleagues show that intralesional therapy using the immunocytokine L19–IL2 elicited a high rate of clinical and… Expand
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Highly Cited
2013
Highly Cited
2013
Systemic high-dose IL2 promotes long-term survival in a subset of metastatic melanoma patients, but this treatment is accompanied… Expand
Highly Cited
2012
Highly Cited
2012
OBJECTIVE Recent studies indicate that regulatory T cells (Tregs) attenuate murine atherosclerosis. Since interleukin (IL)-2… Expand
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Highly Cited
2011
Highly Cited
2011
Purpose: L19-IL2 is an immunocytokine composed of an antibody fragment specific to the EDB domain of fibronectin, a tumor… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND L19-IL2, a tumour-targeting immunocytokine composed of the recombinant human antibody fragment L19 (specific to the… Expand
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2010
2010
L19‐IL2 and L19TNFα are fusion proteins composed of L19(scFv), specific for the angiogenesis‐associated ED‐B containing… Expand
Highly Cited
2009
Highly Cited
2009
The antibody-mediated delivery of therapeutic agents to sites of angiogenesis is an attractive strategy for anticancer therapy… Expand
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Highly Cited
2008
Highly Cited
2008
Purpose: Effective control of pancreatic cancer has been hampered primarily by the lack of tumor specificity of current treatment… Expand
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