L19-IL2 Monoclonal Antibody-Cytokine Fusion Protein
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The intratumoral injection of cytokines, in particular IL2, has shown promise for cutaneous melanoma patients with… Expand Purpose: Radiotherapy modifies the tumor microenvironment and causes the release of tumor antigens, which can enhance the effect… Expand Weide and colleagues show that intralesional therapy using the immunocytokine L19–IL2 elicited a high rate of clinical and… Expand Systemic high-dose IL2 promotes long-term survival in a subset of metastatic melanoma patients, but this treatment is accompanied… Expand OBJECTIVE
Recent studies indicate that regulatory T cells (Tregs) attenuate murine atherosclerosis. Since interleukin (IL)-2… Expand Purpose: L19-IL2 is an immunocytokine composed of an antibody fragment specific to the EDB domain of fibronectin, a tumor… Expand BACKGROUND
L19-IL2, a tumour-targeting immunocytokine composed of the recombinant human antibody fragment L19 (specific to the… Expand L19‐IL2 and L19TNFα are fusion proteins composed of L19(scFv), specific for the angiogenesis‐associated ED‐B containing… Expand The antibody-mediated delivery of therapeutic agents to sites of angiogenesis is an attractive strategy for anticancer therapy… Expand Purpose: Effective control of pancreatic cancer has been hampered primarily by the lack of tumor specificity of current treatment… Expand