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L19-IL2 Monoclonal Antibody-Cytokine Fusion Protein

Known as: L19-IL2 
An immunoconjugate consisting of the recombinant form of the cytokine interleukin-2 (IL-2) fused to a human single-chain Fv (scFv) antibody fragment… 
National Institutes of Health

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NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Antibody-based delivery of tumor necrosis factor (L19-TNFα) and interleukin-2 (L19-IL2) to tumor-associated blood vessels has potent immunological and anticancer activity in the syngeneic J558L BALB…
PurposeTo analyze the impact of TNFα or IL2 on human lymphocytes in vitro and the anti-tumor and immune-modifying effects of L19… 
2017
2017
The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses
ABSTRACT Recently, we have shown that the administration of the tumour-targeted antibody-based immunocytokine L19-IL2 after… 
Review
2016
Review
2016
Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells
The interaction of tumor cells with the microenvironment is like a relationship between the “seeds” and “soil,” which is a… 
Highly Cited
2015
Highly Cited
2015
Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: results of a phase II study
Abstract The intratumoral injection of cytokines, in particular IL2, has shown promise for cutaneous melanoma patients with… 
2015
2015
Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model.
Highly Cited
2013
Highly Cited
2013
The immunocytokine L19-IL2 eradicates cancer when used in combination with CTLA-4 blockade or with L19-TNF.
Systemic high-dose IL2 promotes long-term survival in a subset of metastatic melanoma patients, but this treatment is accompanied… 
Highly Cited
2011
Highly Cited
2011
A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma
Purpose: L19-IL2 is an immunocytokine composed of an antibody fragment specific to the EDB domain of fibronectin, a tumor… 
Highly Cited
2010
Highly Cited
2010
Therapy‐induced antitumor vaccination in neuroblastomas by the combined targeting of IL‐2 and TNFα
L19‐IL2 and L19TNFα are fusion proteins composed of L19(scFv), specific for the angiogenesis‐associated ED‐B containing… 
Highly Cited
2008
Highly Cited
2008
The Targeted Immunocytokine L19-IL2 Efficiently Inhibits the Growth of Orthotopic Pancreatic Cancer
Purpose: Effective control of pancreatic cancer has been hampered primarily by the lack of tumor specificity of current treatment… 
2008
2008
Phase I/II study of the tumor-targeting human L19-IL2 monoclonal antibody-cytokine fusion protein in patients with advanced renal cell carcinoma
16032 Background: L19-IL2 is a tumor targeted immunocytokine constituted by a single chain Fragment variable (scFv) format… 
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