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L-F001 compound

 
National Institutes of Health

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2 relations

Broader (2)

AzepinesSulfonamides

Papers overview

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2017
2017
L‐F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF‐&kgr;B inhibition and Nrf2 pathway activation
Abstract Microglia and astrocytes are largely responsible for inflammatory injury in the brain of Alzheimer's disease (AD… Expand
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2016
2016
L-F001, a Multifunction ROCK Inhibitor Prevents 6-OHDA Induced Cell Death Through Activating Akt/GSK-3beta and Nrf2/HO-1 Signaling Pathway in PC12 Cells and Attenuates MPTP-Induced Dopamine Neuron…
Amounting evidences demonstrated that Rho/Rho-associated kinase (ROCK) might be a novel target for the therapy of Parkinson’s… Expand
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2015
2015
L-F001, a multifunctional ROCK inhibitor prevents paraquat-induced cell death through attenuating ER stress and mitochondrial dysfunction in PC12 cells.
Paraquat (PQ) was demonstrated to induce dopaminergic neuron death and is used as a Parkinson's disease (PD) mimetic. Amounting… Expand
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2012
2012
A monoclonal antibody against a potential cancer biomarker, human ubiquitin-conjugating enzyme E2.
Human ubiquitin-conjugating enzyme E2, also known as UbcH10, is defined as a cyclin-selective ubiquitin carrier protein and is… Expand
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