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L 2286
Known as:
L-2286
, L2286 compound
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Chronic PARP-1 inhibition reduces carotid vessel remodeling and oxidative damage of the dorsal hippocampus in spontaneously hypertensive rats
K. Erős
,
K. Magyar
,
+8 authors
R. Halmosi
PLoS ONE
2017
Corpus ID: 16982794
Vascular remodeling during chronic hypertension may impair the supply of tissues with oxygen, glucose and other compounds…
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2014
2014
A quinazoline-derivative compound with PARP inhibitory effect suppresses hypertension-induced vascular alterations in spontaneously hypertensive rats.
K. Magyar
,
L. Deres
,
+9 authors
R. Halmosi
Biochimica et Biophysica Acta
2014
Corpus ID: 28169885
2014
2014
PARP-Inhibitor Treatment Prevents Hypertension Induced Cardiac Remodeling by Favorable Modulation of Heat Shock Proteins, Akt-1/GSK-3β and Several PKC Isoforms
L. Deres
,
É. Bartha
,
+9 authors
R. Halmosi
PLoS ONE
2014
Corpus ID: 1918571
Spontaneously hypertensive rat (SHR) is a suitable model for studies of the complications of hypertension. It is known that…
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2011
2011
Regulation of Kinase Cascade Activation and Heat Shock Protein Expression by Poly(ADP-ribose) Polymerase Inhibition in Doxorubicin-induced Heart Failure
É. Bartha
,
Izabella Solti
,
+10 authors
R. Halmosi
Journal of Cardiovascular Pharmacology
2011
Corpus ID: 2268135
Cardiomyopathy is one of the most severe side effects of the chemotherapeutic agent doxorubicin (DOX). The formation of reactive…
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2010
2010
A Novel PARP Inhibitor L-2286 in a Rat Model of Impact Acceleration Head Injury: An Immunohistochemical and Behavioral Study
Erzsébet Kövesdi
,
P. Bukovics
,
+7 authors
A. Büki
International Journal of Molecular Sciences
2010
Corpus ID: 13157174
We examined the neuro/axono-protective potential of a novel poly (ADP-ribose) polymerase (PARP) inhibitor L-2286 in a rat impact…
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Highly Cited
2009
Highly Cited
2009
PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats.
É. Bartha
,
Izabella Solti
,
+9 authors
K. Toth
Cardiovascular Research
2009
Corpus ID: 14063948
AIMS Oxidative stress followed by abnormal signalling can play a critical role in the development of long-term, high blood…
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2008
2008
Effect of L-2286, a Poly(ADP-ribose)polymerase Inhibitor and Enalapril on Myocardial Remodeling and Heart Failure
É. Bartha
,
G. Kiss
,
+7 authors
R. Halmosi
Journal of Cardiovascular Pharmacology
2008
Corpus ID: 205598508
Increased activation of poly(ADP-ribose) polymerase (PARP) enzyme has been implicated in the pathogenesis of acute and chronic…
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Highly Cited
2006
Highly Cited
2006
PARP inhibition prevents postinfarction myocardial remodeling and heart failure via the protein kinase C/glycogen synthase kinase-3beta pathway.
A. Pálfi
,
Ambrus Tóth
,
+10 authors
R. Halmosi
Journal of Molecular and Cellular Cardiology
2006
Corpus ID: 7748051
Highly Cited
2005
Highly Cited
2005
The Role of Akt and Mitogen-Activated Protein Kinase Systems in the Protective Effect of Poly(ADP-Ribose) Polymerase Inhibition in Langendorff Perfused and in Isoproterenol-Damaged Rat Hearts
A. Pálfi
,
Ambrus Tóth
,
+10 authors
K. Toth
Journal of Pharmacology and Experimental…
2005
Corpus ID: 15954310
Blocking poly(ADP-ribosyl)ation of nuclear proteins protects the heart from ischemia-reperfusion injury. In addition, activation…
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