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Nivolumab, a fully human IgG4 programmed death 1 (PD-1) immune-checkpoint-inhibitor antibody, disrupts PD-1-mediated… Expand BACKGROUND
Blockade of programmed death 1 (PD-1), an inhibitory receptor expressed by T cells, can overcome immune resistance. We… Expand BACKGROUND
Programmed death 1 (PD-1) protein, a T-cell coinhibitory receptor, and one of its ligands, PD-L1, play a pivotal role… Expand BACKGROUND
An improvement in overall survival among patients with metastatic melanoma has been an elusive goal. In this phase 3… Expand SERIES “ATS/ERS TASK FORCE: STANDARDISATION OF LUNG FUNCTION TESTING”
Edited by V. Brusasco, R. Crapo and G. Viegi
Number 5… Expand BACKGROUND
Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and… Expand BACKGROUND
The influence of excess body weight on the risk of death from cancer has not been fully characterized.
In a… Expand BACKGROUND
Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma… Expand BACKGROUND
Type 2 diabetes mellitus is increasingly common, primarily because of increases in the prevalence of a sedentary… Expand BACKGROUND
Leptin, the product of the ob gene, is a hormone secreted by adipocytes. Animals with mutations in the ob gene are… Expand