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KU 55933

Known as: KU-55933, KU55933 
National Institutes of Health

Papers overview

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2016
2016
PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway
PICT-1 is an essential ribosome biogenesis factor whose loss induces p53 accumulation and apoptosis. Here, we show that DNA… 
Highly Cited
2016
Highly Cited
2016
Induction of ROS-independent DNA damage by curcumin leads to G2/M cell cycle arrest and apoptosis in human papillary thyroid carcinoma BCPAP cells.
Previously we found that curcumin, the active constituent of dietary spice turmeric, showed potent inhibitory effects on the cell… 
2015
2015
Bacterial Genotoxins Promote Inside-Out Integrin β1 Activation, Formation of Focal Adhesion Complexes and Cell Spreading
Integrins are membrane bound receptors that regulate several cellular processes, such as cell adhesion, migration, survival and… 
2013
2013
Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation.
2013
2013
Ataxia telangiectasia mutated impacts insulin‐like growth factor 1 signalling in skeletal muscle
•  What is the central question of this study? In some cultured cells, ataxia telangiectasia mutated (ATM) is required for… 
2013
2013
The effect of ATM kinase inhibition on the initial response of human dental pulp and periodontal ligament mesenchymal stem cells to ionizing radiation
Abstract Purpose: This study evaluates early changes in human mesenchymal stem cells (MSC) isolated from dental pulp and… 
2011
2011
An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.
In response to DNA damage, transcription is blocked by inhibition of RNA polymerase II activity. The regulation of a preexisting… 
2011
2011
DNA-Dependent Protein Kinase and Ataxia Telangiectasia Mutated (ATM) Promote Cell Survival in Response to NK314, a Topoisomerase IIα Inhibitor
4-Hydroxy-5-methoxy-2,3-dihydro-1H-[1,3]benzodioxolo[5,6-c]pyrrolo[1,2-f]-phenanthridium chloride (NK314) is a benzo[c… 
2011
2011
Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells
In the present study dopaminergic neuroblastoma B65 cells were exposed to Camptothecin (CPT) (0.5–10 μM), either alone or in the… 
2011
2011
Cadmium induced radioadaptive response via an ATM-independent H(2)S/cystathionine γ-lyase modulation.
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