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KU 2285

Known as: KU-2285 
National Institutes of Health

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Nitroimidazoles

Papers overview

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1995
1995
Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): radiosensitization efficiency and toxicity.
1994
1994
Combined cytokinesis-block micronucleus and chromosomal aberration assay for the evaluation of radiosensitizers at low radiation doses.
1994
1994
Reoxygenation in the SCCVII tumor after KU-2285 sensitization plus single or fractionated irradiation.
1994
1994
Metabolic studies and neurotoxicity in tumors and brain of mice after hypoxic cell sensitizers.
1993
1993
In vivo radiosensitization efficacy of KU-2285 and etanidazole at clinically relevant low radiation doses.
1992
1992
Radiosensitization efficacy of KU-2285, RP-170 and etanidazole at low radiation doses: assessment by in vitro cytokinesis-block micronucleus assay.
Since the cytokinesis-block micronucleus assay is very sensitive at low radiation doses, we used it to investigate the in vitro… 
1992
1992
Fluorine modification of nitroazole radiosensitizers for the enhancement of sensitizing activity with lowering toxicity: a pharmacokinetic characterization.
1992
1992
Pharmacokinetics of fluorinated 2-nitroimidazole hypoxic cell radiosensitizers in murine peripheral nervous tissue.
We have previously reported that KU-2285, a 2-nitroimidazole with a fluorinated N1-substituent (-CH2-CF2CONH(CH2)nOH, n = 2), was… 
1991
1991
A fluorinated 2-nitroimidazole, KU-2285, as a new hypoxic cell radiosensitizer.
1989
1989
Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers.
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