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KU-0060648

National Institutes of Health

Papers overview

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2017
2017
Feedback autophagy activation as a key resistance factor of Ku-0060648 in colorectal cancer cells.
2016
2016
KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms
Here we tested anti-tumor activity of KU-0060648 in preclinical hepatocellular carcinoma (HCC) models. Our results demonstrated… 
2010
2010
Abstract 5780: Development of potent inhibitors of the DNA-dependent protein kinase (DNA-PK)
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC The cellular response to DNA double-strand break… 
2008
2008
Potent in vitro and in vivo radiosensitisation by the selective DNA-dependent protein kinase inhibitor KU-0060648
406 An important determinant of the susceptibility of cancer cells to DNA damaging anti-cancer therapeutics is the ability of the… 
2008
2008
Chemosensitisation of cancer cells by KU-0060648, a potent and selective inhibitor of DNA-PK
4080 DNA double strand breaks (DSB) are profoundly cytotoxic unless rapidly repaired. Non-homologous end joining (NHEJ) is the… 
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