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e16555Background: KREMEN2 is an important regulator of classical Wnt/β-catenin signaling pathway. However, the relationship… Expand In multicellular organisms, cell death pathways allow the removal of abnormal or unwanted cells. Their dysregulation can lead… Expand Cochlear hair cells (HCs), the sensory cells that respond to sound, do not regenerate after damage in adult mammals, and their… Expand Lipoprotein (a) [Lp(a)] is an independent risk factor for atherosclerosis-related events that is under strong genetic control… Expand The canonical Wnt/β-catenin pathway plays a key role in the regulation of bone remodeling in mice and humans. Two transmembrane… Expand Wnt signalling is a key pathway controlling bone formation in mice and humans. One of the regulators of this pathway is Dkk1… Expand Background The low density lipoprotein receptor-related protein-6 (LRP6) is an essential co-receptor for canonical Wnt signaling… Expand Kremen 1 and 2 (Krm1/2) are transmembrane receptors for Wnt antagonists of the Dickkopf (Dkk) family and function by inhibiting… Expand Kremen1 and 2 (Krm1/2) are coreceptors for Dickkopf1 (Dkk1), an antagonist of Wnt/β-catenin signaling, and play a role in head… Expand Dickkopf1 (Dkk1) is a secreted antagonist of the Wnt/beta-catenin signaling pathway that acts by direct binding to and inhibiting… Expand