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KREMEN2 gene

Known as: KRM2, MGC10791, kringle containing transmembrane protein 2 
 
National Institutes of Health

Papers overview

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2019
2019
Kremen1-induced cell death is regulated by homo- and heterodimerization
In multicellular organisms, cell death pathways allow the removal of abnormal or unwanted cells. Their dysregulation can lead… Expand
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2016
2016
Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice.
UNLABELLED Cochlear hair cells (HCs), the sensory cells that respond to sound, do not regenerate after damage in adult mammals… Expand
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2015
2015
Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.
Lipoprotein (a) [Lp(a)] is an independent risk factor for atherosclerosis-related events that is under strong genetic control… Expand
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2014
2014
Osteoblast-Specific Krm2 Overexpression and Lrp5 Deficiency Have Different Effects on Fracture Healing in Mice
The canonical Wnt/β-catenin pathway plays a key role in the regulation of bone remodeling in mice and humans. Two transmembrane… Expand
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2010
2010
Negative Regulation of Bone Formation by the Transmembrane Wnt Antagonist Kremen-2
Wnt signalling is a key pathway controlling bone formation in mice and humans. One of the regulators of this pathway is Dkk1… Expand
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2010
2010
Dkk1 Stabilizes Wnt Co-Receptor LRP6: Implication for Wnt Ligand-Induced LRP6 Down-Regulation
BACKGROUND The low density lipoprotein receptor-related protein-6 (LRP6) is an essential co-receptor for canonical Wnt signaling… Expand
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Highly Cited
2008
Highly Cited
2008
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density.
Kremen1 and Kremen2 (Krm1 and Krm2) are transmembrane coreceptors for Dickkopf1 (Dkk1), an antagonist of Wnt/beta-catenin… Expand
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2007
2007
Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.
Kremen 1 and 2 (Krm1/2) are transmembrane receptors for Wnt antagonists of the Dickkopf (Dkk) family and function by inhibiting… Expand
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2006
2006
The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition.
Kremen1 and 2 (Krm1/2) are coreceptors for Dickkopf1 (Dkk1), an antagonist of Wnt/beta-catenin signaling, and play a role in head… Expand
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Highly Cited
2003
Highly Cited
2003
Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling.
Dickkopf1 (Dkk1) is a secreted antagonist of the Wnt/beta-catenin signaling pathway that acts by direct binding to and inhibiting… Expand
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