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KR 31378

Known as: KR-31378, KR31378 
National Institutes of Health

Papers overview

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2009
2009
KR-31378, a potassium-channel opener, induces the protection of retinal ganglion cells in rat retinal ischemic models.
KR-31378 is a newly developed K(ATP)-channel opener. To investigate the ability of KR-31378 to protect retinal ganglion cells… 
2006
2006
Effects of KR-31378, a novel ATP-sensitive potassium channel activator, on hypertrophy of H9c2 cells and on cardiac dysfunction in rats with congestive heart failure.
2005
2005
Protective effect of KR-31378 on oxidative stress in cardiac myocytes
In this study, we investigated whether a novel anti-ischemic KATP opener KR-31378 [(2S,3S,4R)-N”-cyano-N-(6-amino-3,4-dihydro-3… 
2004
2004
KR‐31378 ameliorates atherosclerosis by blocking monocyte recruitment in hypercholestrolemic mice
The recruitment of monocytes into the artery wall is a crucial early step in atherogenesis. A novel compound, KR‐31378, has been… 
2004
2004
Neuroprotective effect of KR-31378 via KATP channel opening against ischemic insult.
The opening of the adenosine triphosphate (ATP)-sensitive potassium (KATP) channel has been proposed as a therapeutic approach… 
2004
2004
Dose-dependent pharmacokinetics of KR-31378, a new neuroprotective agent for ischaemia-reperfusion damage in dogs.
Dose-dependent pharmacokinetic parameters of KR-31378, a new neuroprotective agent for ischaemia-reperfusion damage, were… 
2003
2003
Characterization of the physicochemical properties of KR-31378
KR-31378 is a new drug candidate intended for the use in the prevention of ischemia-reperfusion damage. The objective of this… 
2002
2002
Neuroprotective effect of (2S,3S,4R)-N"-cyano-N-(6-amino-3, 4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378), a benzopyran analog, against focal…
This study shows the preventive effect of KR-31378 [(2S,3S,4R)-N"-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2… 
2001
2001
Differential action of KR‐31378, a novel potassium channel activator, on cardioprotective and hemodynamic effects
The cardioprotective and hemodynamic effects of KR‐31378, a highly cardioselective ATP‐sensitive potassium channel activator with… 
2000
2000
Dose-dependent pharmacokinetics of a new neuroprotective agent for ischemia-reperfusion damage, KR-31378, in rats.
The dose-dependent pharmacokinetic parameters of a new neuroprotective agent for ischemia-reperfusion damage, KR-31378, were… 
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