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KML001

National Institutes of Health

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sodium arsenite

Papers overview

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2019
2019
Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
[This corrects the article DOI: 10.1371/journal.pone.0137589.]. 
2017
2017
Downregulation of androgen receptors by NaAsO2 via inhibition of AKT‐NF‐κB and HSP90 in castration resistant prostate cancer
Androgen and androgen receptor (AR) play essential roles in the development and maintenance of prostate cancer. The recently… 
2016
2016
Anti-tumoral effect of arsenic compound, sodium metaarsenite (KML001), in non-Hodgkin’s lymphoma: an in vitro and in vivo study
SummaryArsenic compounds have been used in traditional medicine for several centuries. KML001 (sodium metaarsenite; NaAsO2) is an… 
2015
2015
KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
We investigated the effects of KML001 (NaAsO2, sodium metaarsenite, Kominox), an orally bioavailable arsenic compound, on the… 
2013
2013
KML001 Displays Vascular Disrupting Properties and Irinotecan Combined Antitumor Activities in a Murine Tumor Model
KML001 is sodium metaarsenite, and has shown cytotoxic activity in human tumor cell lines. The anti-cancer mechanism of KML001… 
2012
2012
Telomere and Microtubule Targeting in Treatment-Sensitive and Treatment-Resistant Human Prostate Cancer Cells
Modulating telomere dynamics may be a useful strategy for targeting prostate cancer cells, because they generally have short… 
2010
2010
Sodium metaarsenite (KML001) induces a G1 phase arrest in HCT116 colorectal cancer cells
Arsenic‐based reagents have been used as medicines, but they can cause chromosomal abnormalities in vitro and in vivo. Recent… 
2008
2008
KML001 Cytotoxic Activity Is Associated with Its Binding to Telomeric Sequences and Telomere Erosion in Prostate Cancer Cells
Purpose: KML001 (sodium metaarsenite) is an orally bioavailable arsenic compound that has entered phase I/II clinical trials in… 
2008
2008
KML 001 Cytotoxic Activity Is Associated with Its Binding toTelomeric Sequences andTelomere Erosion in Prostate Cancer Cells
Purpose: KML001 (sodium metaarsenite) is an orally bioavailable arsenic compound that has entered phase I/II clinical trials in… 
2004
2004
436 The novel compound KML001 induces telomere attrition, senescence and chromosomal instability in cell lines with short telomeres
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