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KLRB1 protein, human

Known as: hNKR-P1A, KLRB1, killer cell lectin-like receptor subfamily B, member 1 protein, human 
Killer cell lectin-like receptor subfamily B member 1 (225 aa, ~25 kDa) is encoded by the human KLRB1 gene. This protein plays a role in the… 
National Institutes of Health

Related topics

Related topics

15 relations
Cell Adhesion MoleculesCytoplasmic DomainGlycoproteinsHomo sapiens

Papers overview

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Highly Cited
2014
Highly Cited
2014
CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages
Highly Cited
2011
Highly Cited
2011
Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis.
OBJECTIVE To investigate the phenotype and function of CD4+ T cells in synovial fluid (SF) from the affected joints of children… 
Highly Cited
2010
Highly Cited
2010
CD161 is a marker of all human IL‐17‐producing T‐cell subsets and is induced by RORC
We have previously shown that human Th17 lymphocytes are characterized by the selective expression of IL‐23 receptor (IL‐23R… 
Highly Cited
2009
Highly Cited
2009
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
The C-type lectin-like receptor CD161, which has recently been described to promote T cell expansion, is expressed on a discrete… 
Highly Cited
2009
Highly Cited
2009
Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORγt
Recent studies have suggested a close relationship between CD4+FOXP3+ regulatory T cells (Tregs) and proinflammatory IL-17… 
Highly Cited
2005
Highly Cited
2005
Cutting Edge: Lectin-Like Transcript-1 Is a Ligand for the Inhibitory Human NKR-P1A Receptor1
Increasingly, roles are emerging for C-type lectin receptors in immune regulation. One receptor whose function has remained… 
Highly Cited
2001
Highly Cited
2001
CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells
In this study we present new differential characteristics of NK cells expressing CD56 surface antigen in low (CD56dim) or high… 
Highly Cited
1998
Highly Cited
1998
CD161 (NKR-P1A) Costimulation of CD1d-dependent Activation of Human T Cells Expressing Invariant Vα24JαQ T Cell Receptor α Chains
A population of human T cells expressing an invariant Vα24JαQ T cell antigen receptor (TCR) α chain and high levels of CD161 (NKR… 
Highly Cited
1997
Highly Cited
1997
Association with FcRγ Is Essential for Activation Signal through NKR-P1 (CD161) in Natural Killer (NK) Cells and NK1.1+ T Cells
Natural killer (NK) cells exhibit cytotoxicity against variety of tumor cells and virus-infected cells without prior… 
Highly Cited
1994
Highly Cited
1994
Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes.
In rodents, the NKR-P1 family of glycoproteins are preferentially expressed on NK cells and have been implicated in NK cell… 
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