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KLB protein, human

Known as: Klotho Beta-Like Protein, BetaKlotho, beta-klotho protein, human 
Beta-klotho (1044 aa, ~120 kDa) is encoded by the human KLB gene. This protein is involved in the regulation of growth factor-dependent signaling.
National Institutes of Health

Related topics

Related topics

10 relations
Growth Factor BindingIntegral Membrane ProteinsKLB genePlasma membrane

Broader (1)

Membrane Proteins

Papers overview

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Highly Cited
2017
Highly Cited
2017
A Novel Oral Fluid Assay (LC-QTOF-MS) for the Detection of Fentanyl and Clandestine Opioids in Oral Fluid After Reported Heroin Overdose
The adulteration of heroin with non-pharmaceutical fentanyl and other high-potency opioids is one of the factors contributing to… 
Highly Cited
2017
Highly Cited
2017
FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
Highly Cited
2012
Highly Cited
2012
Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB
Background Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of… 
Highly Cited
2009
Highly Cited
2009
Different roles of N‐ and C‐ termini in the functional activity of FGF21
Fibroblast growth factor 21 is a member of endocrine FGFs subfamily, along with FGF19 and FGF23. It is emerging as a novel… 
Highly Cited
2009
Highly Cited
2009
Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice
FGF19 is a hormone that regulates bile acid and glucose homeostasis. Progress has been made in identifying cofactors for receptor… 
Review
2008
Review
2008
Actions and mode of actions of FGF19 subfamily members.
Fibroblast growth factors (FGFs) are humoral factors with diverse biological functions. While most FGFs were shown to work as… 
Highly Cited
2008
Highly Cited
2008
C-terminal Tail of FGF19 Determines Its Specificity toward Klotho Co-receptors*
FGF19 subfamily proteins (FGF19, FGF21, and FGF23) are unique members of fibroblast growth factors (FGFs) that regulate energy… 
Review
2008
Review
2008
The Klotho gene family and the endocrine fibroblast growth factors
Purpose of reviewThis review summarizes recent progress in understanding of Klotho and βKlotho function in the regulation of… 
Highly Cited
2007
Highly Cited
2007
Co-receptor Requirements for Fibroblast Growth Factor-19 Signaling*
FGF19 is a unique member of the fibroblast growth factor (FGF) family of secreted proteins that regulates bile acid homeostasis… 
Highly Cited
2005
Highly Cited
2005
Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho.
We have generated a line of mutant mouse that lacks betaKlotho, a protein that structurally resembles Klotho. The synthesis and… 
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