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KIN-193

 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
N6-methyladenosine mRNA methylation of PIK3CB regulates AKT signalling to promote PTEN-deficient pancreatic cancer progression
Objective Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Thus far, most drugs have failed… Expand
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2019
2019
Molecular profiling establishes genetic features predictive of the efficacy of the p110β inhibitor KIN-193.
Aberrant activation of the PI3K pathway is a common alteration in human cancers. Therapeutic intervention targeting the PI3K… Expand
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Highly Cited
2012
Highly Cited
2012
Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent.
UNLABELLED Genetic approaches have shown that the p110β isoform of class Ia phosphatidylinositol-3-kinase (PI3K) is essential for… Expand
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2012
2012
Beta-testing of PI3-kinase inhibitors: is beta better?
Although it has been known for some time that PTEN-null tumors require expression of the p110β isoform of phosphoinositide 3… Expand
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