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KF58333
Known as:
KF 58333
, KF-58333
, Radicicol Derivative KF58333
A novel oxime derivative of radicicol that destabilizes the hsp90 client proteins, such as erbB2, raf-1 and AKT, which are essential for tumor cell…
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National Institutes of Health
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Lactones
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1999
1999
Binding Signaling Molecules Antitumor Activity via Selective Depletion of Hsp 90 Vivo in KF 25706 , a Novel Oxime Derivative of Radicicol , Exhibits
S. Soga
,
L. Neckers
,
+8 authors
S. Akinaga
1999
Corpus ID: 16911582
Radicicol, a macrocyclic antifungal antibiotic, has been shown to bind to the heat shock protein 90 (Hsp90) chaperone…
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