KEAP1 gene

Known as: MGC9454, kelch-like family member 19, Kelch-Like ECH-Associated Protein 1 Gene 
This gene is involved in ubiquitin-mediated protein degradation.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
The Keap1–Nrf2 regulatory pathway plays a central role in the protection of cells against oxidative and xenobiotic damage. Under… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2009
Review
2009
Nrf2:INrf2 (Keap1) are cellular sensors of chemical- and radiation-induced oxidative and electrophilic stress. Nrf2 is a nuclear… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2006
Highly Cited
2006
BACKGROUND Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-sensitive transcription factor that positively regulates… (More)
Is this relevant?
Review
2004
Review
2004
The transcription factor Nrf2 regulates the basal and inducible expression of numerous detoxifying and antioxidant genes. The… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress proteins in… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
The bZIP transcription factor Nrf2 controls a genetic program that protects cells from oxidative damage and maintains cellular… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Keap1 is a negative regulator of Nrf2, a bZIP transcription factor that mediates adaptation to oxidative stress. Previous studies… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Coordinate induction of phase 2 proteins and elevation of glutathione protect cells against the toxic and carcinogenic effects of… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated induction of phase II detoxifying… (More)
Is this relevant?