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KCNE proteins are single transmembrane-segment voltage-gated potassium (Kv) channel ancillary subunits that exhibit a diverse… Expand The diversity of the voltage-gated K+ (Kv) channel subfamily Kv2 is increased by interactions with auxiliary β-subunits and by… Expand Background—Brugada syndrome (BrS) has a significantly higher incidence among the male sex. Among genes coding ion channels and… Expand BACKGROUND
Atrial fibrillation (AF) is the most common clinical arrhythmia and a major cause of cardiovascular morbidity and… Expand OBJECTIVE
The voltage-gated K+ channel KCNQ1 associates with the small KCNE1 beta subunit to underlie the IKs repolarizing… Expand Voltage-gated potassium (K(V)) channels are modulated by at least three distinct classes of proteins including the KCNE family of… Expand The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion… Expand BACKGROUND
Long QT syndrome [LQTS] is a congenital cardiac disease characterised by prolonged QTC-time, syncopes and sudden… Expand The function of the KCNE5 (KCNE1-like) protein has not previously been described. Here we show that KCNE5 induces both a time… Expand We describe the identification and characterization of a new gene deleted in the AMME contiguous gene syndrome. This gene is… Expand