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KB 141

Known as: KB-141, KB141 cpd 
 
National Institutes of Health

Papers overview

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2018
2018
The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular… Expand
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2014
2014
Mutations in thyroid hormone receptors (TRs) often lead to metabolic and developmental disorders, but patients with these… Expand
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2012
2012
Subtype‐selective thyromimetics have potential as new pharmaceuticals for the prevention or treatment of heart disease, high LDL… Expand
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Highly Cited
2008
Highly Cited
2008
Selective thyroid hormone receptor subtype-beta (TRbeta) agonists have received attention as potential treatments for… Expand
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Review
2008
Review
2008
The processes and pathways mediating the intermediary metabolism of carbohydrates, lipids, and proteins are all affected by… Expand
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Highly Cited
2007
Highly Cited
2007
Despite efforts spanning four decades, the therapeutic potential of thyroid hormone receptor (TR) agonists as lipid-lowering and… Expand
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Review
2007
Review
2007
Obesity and metabolic syndrome are increasing dramatically worldwide, contributing to cardiovascular morbidity and mortality… Expand
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2007
2007
  • N. Garg, Y. Li, +16 authors J. Malm
  • Bioorganic & medicinal chemistry letters
  • 2007
  • Corpus ID: 8348687
Based on the scaffold of the pharmacologically selective thyromimetic 2b, structurally a close analog to KB-141 (2a), a number of… Expand
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2006
2006
Based on the examination of the X-ray crystallographic structures of the LBD of TRalpha and TRbeta in complex with KB-141 (2), a… Expand
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Highly Cited
2003
Highly Cited
2003
Few treatments for obesity exist and, whereas efficacious therapeutics for hyperlipidemia are available, further improvements are… Expand
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