KB 141

Known as: KB-141, KB141 cpd 
 
National Institutes of Health

Papers overview

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2014
2014
Mutations in thyroid hormone receptors (TRs) often lead to metabolic and developmental disorders, but patients with these… (More)
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2012
2012
Subtype-selective thyromimetics have potential as new pharmaceuticals for the prevention or treatment of heart disease, high LDL… (More)
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2008
2008
Selective thyroid hormone receptor subtype-beta (TRbeta) agonists have received attention as potential treatments for… (More)
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Review
2008
Review
2008
The processes and pathways mediating the intermediary metabolism of carbohydrates, lipids, and proteins are all affected by… (More)
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Highly Cited
2007
Highly Cited
2007
Despite efforts spanning four decades, the therapeutic potential of thyroid hormone receptor (TR) agonists as lipid-lowering and… (More)
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2007
2007
Based on the scaffold of the pharmacologically selective thyromimetic 2b, structurally a close analog to KB-141 (2a), a number of… (More)
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Review
2007
Review
2007
Obesity and metabolic syndrome are increasing dramatically worldwide, contributing to cardiovascular morbidity and mortality… (More)
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2006
2006
Based on the examination of the X-ray crystallographic structures of the LBD of TRalpha and TRbeta in complex with KB-141 (2), a… (More)
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Review
2005
Review
2005
Few treatments for obesity exist and improvements for treatment of hyperlipidemia are still desirable. Thyroid hormone receptors… (More)
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Highly Cited
2003
Highly Cited
2003
Few treatments for obesity exist and, whereas efficacious therapeutics for hyperlipidemia are available, further improvements are… (More)
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