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KB 141

Known as: KB-141, KB141 cpd 
National Institutes of Health

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2 relations

Broader (2)

Phenyl EthersPhenylacetates

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Analysis of the roles of mutations in thyroid hormone receptor-β by a bacterial biosensor system.
Mutations in thyroid hormone receptors (TRs) often lead to metabolic and developmental disorders, but patients with these… 
2012
2012
Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1
Review
2008
Review
2008
Metabolic effects of thyroid hormone derivatives.
The processes and pathways mediating the intermediary metabolism of carbohydrates, lipids, and proteins are all affected by… 
Highly Cited
2008
Highly Cited
2008
Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor β subtype selective agonist KB-141
2008
2008
Les analogues des hormones thyroïdiennes : un apport biologique important et de nouvelles possibilités thérapeutiques
Highly Cited
2007
Highly Cited
2007
Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index
Despite efforts spanning four decades, the therapeutic potential of thyroid hormone receptor (TR) agonists as lipid-lowering and… 
Review
2007
Review
2007
Therapeutic potential for thyroid hormone receptor-beta selective agonists for treating obesity, hyperlipidemia and diabetes.
Obesity and metabolic syndrome are increasing dramatically worldwide, contributing to cardiovascular morbidity and mortality… 
Review
2006
Review
2006
Development of the thyroid hormone receptor beta-subtype agonist KB-141: a strategy for body weight reduction and lipid lowering with minimal cardiac side effects.
Few treatments for obesity exist and improvements for treatment of hyperlipidemia are still desirable. Thyroid hormone receptors… 
2006
2006
Thyroid receptor ligands. Part 4: 4'-amido bioisosteric ligands selective for the thyroid hormone receptor beta.
Highly Cited
2003
Highly Cited
2003
Selective thyroid hormone receptor-β activation: A strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability
Few treatments for obesity exist and, whereas efficacious therapeutics for hyperlipidemia are available, further improvements are… 
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