KB 141

The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular… Expand

Mutations in thyroid hormone receptors (TRs) often lead to metabolic and developmental disorders, but patients with these… Expand

Subtype‐selective thyromimetics have potential as new pharmaceuticals for the prevention or treatment of heart disease, high LDL… Expand

Selective thyroid hormone receptor subtype-beta (TRbeta) agonists have received attention as potential treatments for… Expand

The processes and pathways mediating the intermediary metabolism of carbohydrates, lipids, and proteins are all affected by… Expand

Despite efforts spanning four decades, the therapeutic potential of thyroid hormone receptor (TR) agonists as lipid-lowering and… Expand

Obesity and metabolic syndrome are increasing dramatically worldwide, contributing to cardiovascular morbidity and mortality… Expand

Based on the scaffold of the pharmacologically selective thyromimetic 2b, structurally a close analog to KB-141 (2a), a number of… Expand

Based on the examination of the X-ray crystallographic structures of the LBD of TRalpha and TRbeta in complex with KB-141 (2), a… Expand

Few treatments for obesity exist and, whereas efficacious therapeutics for hyperlipidemia are available, further improvements are… Expand