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KB 141

Known as: KB-141, KB141 cpd 
National Institutes of Health

Related topics

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2 relations

Broader (2)

Phenyl EthersPhenylacetates

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Thyroid hormone receptor β1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion in mice[S]
The ATP-binding cassette transporter ABCB4/MDR3 is critical for biliary phosphatidylcholine (PC) excretion at the canalicular… 
2014
2014
Analysis of the roles of mutations in thyroid hormone receptor-β by a bacterial biosensor system.
Mutations in thyroid hormone receptors (TRs) often lead to metabolic and developmental disorders, but patients with these… 
2012
2012
Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1
Review
2008
Review
2008
Metabolic effects of thyroid hormone derivatives.
The processes and pathways mediating the intermediary metabolism of carbohydrates, lipids, and proteins are all affected by… 
Highly Cited
2008
Highly Cited
2008
Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor β subtype selective agonist KB-141
2008
2008
[Thyroid hormone analogs: an important biological supply and new therapeutic possibilities].
Review
2007
Review
2007
Therapeutic potential for thyroid hormone receptor-beta selective agonists for treating obesity, hyperlipidemia and diabetes.
Obesity and metabolic syndrome are increasing dramatically worldwide, contributing to cardiovascular morbidity and mortality… 
2007
2007
Anti‐Obesity, Lipid‐lowering, and Anti‐Diabetic Effects of The Selective Thyroid Receptor Beta Agonist KB‐141
Thyroid hormone receptorβ (TRβ) increases metabolic rate (MR) with a shallow dose‐response slope without tachycardia (HR), unlike… 
2007
2007
Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-alpha-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141.
Highly Cited
2003
Highly Cited
2003
Selective thyroid hormone receptor-β activation: A strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability
Few treatments for obesity exist and, whereas efficacious therapeutics for hyperlipidemia are available, further improvements are… 
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