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Janus kinase 3

Known as: Tyrosine-Protein Kinase JAK3, Leukocyte Janus Kinase, JAK3 Protein Tyrosine Kinase 
A Janus kinase subtype that is predominantly expressed in hematopoietic cells. It is involved in signaling from a broad variety of CYTOKINE RECEPTORS… 
National Institutes of Health

Related topics

Related topics

28 relations
Cell Differentiation processCell ProliferationEnzyme GeneHematopoiesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Neural precursor cells inhibit multiple inflammatory signals
Highly Cited
2000
Highly Cited
2000
The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines.
Interleukin (IL)-2, a critical cytokine with indispensable functions in regulating lymphoid homeostasis, induces the activation… 
Review
1999
Review
1999
Janus kinases and their role in growth and disease.
Highly Cited
1997
Highly Cited
1997
Selective Upregulation of Cytokine Receptor Subchain and Their Intracellular Signalling Molecules After Peripheral Nerve Injury
Numerous studies have suggested that growth factors and cytokines play an important role in the survival of injured neurons and… 
Highly Cited
1996
Highly Cited
1996
IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.
We have recently reported that IL-13R may share a component with IL-4R. Here we report that both IL-4 and IL-13 share signaling… 
Highly Cited
1996
Highly Cited
1996
Retroviral-mediated gene correction for X-linked severe combined immunodeficiency.
X-linked severe combined immunodeficiency (XSCID) is a lethal disease caused by a defect in the gene encoding the common gamma… 
Highly Cited
1995
Highly Cited
1995
Interleukin-9 Induces Tyrosine Phosphorylation of Insulin Receptor Substrate-1 via JAK Tyrosine Kinases (*)
Interleukin (IL)-9 stimulates the proliferation of a variety of hematopoietic lineages through its interaction with a receptor of… 
Highly Cited
1995
Highly Cited
1995
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2.
Thrombopoietin (TPO) is a recently characterized growth and differentiation factor for megakaryocytes and platelets that exerts… 
Highly Cited
1995
Highly Cited
1995
Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
A number of cytokines and growth factors use the JAK-STAT pathway to signal from the cell membrane to the nucleus. While… 
Highly Cited
1994
Highly Cited
1994
JAK3 Janus kinase is involved in interleukin 7 signal pathway
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