Janus kinase 3

Known as: Tyrosine-Protein Kinase JAK3, Leukocyte Janus Kinase, JAK3 Protein Tyrosine Kinase 
A Janus kinase subtype that is predominantly expressed in hematopoietic cells. It is involved in signaling from a broad variety of CYTOKINE RECEPTORS… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
UNLABELLED The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well understood. We conducted whole-exome… (More)
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Highly Cited
2011
Highly Cited
2011
Janus kinase 3, a tyrosine kinase expressed in haematopoetic tissues, plays a decisive role in T-lymphocyte survival. JAK3… (More)
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Review
2008
Review
2008
SUMMARY Cytokines play pivotal roles in immunity and inflammation, and targeting cytokines and their receptors is an effective… (More)
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Highly Cited
2004
Highly Cited
2004
Present immunosuppressive therapy in clinical organ transplantation is based on drugs that suppress the immune system in a non… (More)
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Highly Cited
2004
Highly Cited
2004
Identifying regions of the human genome that have been targets of natural selection will provide important insights into human… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The immune response is regulated through a tightly controlled cytokine network. The counteracting balance between… (More)
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Highly Cited
1999
Highly Cited
1999
A novel homology model of the kinase domain of Janus kinase (JAK) 3 was used for the structure-based design of… (More)
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Highly Cited
1997
Highly Cited
1997
We have recently shown that leptin mimicks insulin effects on glucose transport and glycogen synthesis through a… (More)
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Highly Cited
1995
Highly Cited
1995
The cytokines interleukin 2 (IL-2) and IL-15 have similar biological effects on T cells and bind common hematopoietin receptor… (More)
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Highly Cited
1995
Highly Cited
1995
Interleukin (IL-12) has many effects on the function of natural killer and T cells, and is important in the control of cell… (More)
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