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JTT 608
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JTT-608
National Institutes of Health
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2017
2017
INHIBITORS FOR THE TREATMENT OF DABETES
2017
Corpus ID: 55583882
Diabetes Research Foundation, “Diabetes and Your Eyesight.” printed from http://www.glaucoma.org/learn? diabetes and yo. html, 2…
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2005
2005
Daily inhibition of postprandial hyperglycaemia with JTT‐608, a novel oral antidiabetic agent, ameliorates pancreatic function in neonatally streptozotocin‐treated rats
T. Ohta
,
T. Sasase
,
+4 authors
F. Yonemori
Diabetes, obesity and metabolism
2005
Corpus ID: 25487896
Aim: Chronic glycaemic control, in particular, the control of postprandial hyperglycaemia, is essential for preventing the…
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2003
2003
Antidiabetic effect of chronic administration of JTT-608, a new hypoglycemic agent, in diabetic Goto-Kakizaki rats.
T. Ohta
,
K. Miyajima
,
G. Komuro
,
N. Furukawa
,
F. Yonemori
European Journal of Pharmacology
2003
Corpus ID: 35738706
2001
2001
A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism.
N. Itabashi
,
K. Okada
,
+5 authors
T. Saito
Journal of Pharmacology and Experimental…
2001
Corpus ID: 10070404
Insulin secretion from MIN6 cells (a pancreatic beta-cell line) induced by high glucose (greater than 16.8 mM) was potentiated by…
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2001
2001
A new hypoglycemic agent, JTT-608, evokes protein kinase A-mediated Ca(2+) signaling in rat islet beta-cells: strict regulation by glucose, link to insulin release, and cooperation with glucagon-like…
S. Hashiguchi
,
T. Yada
,
T. Arima
Journal of Pharmacology and Experimental…
2001
Corpus ID: 23064628
A new nonsulfonylurea oral hypoglycemic agent, JTT-608, has been reported to stimulate insulin release at elevated, but not low…
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2000
2000
The insulinotropic mechanism of the novel hypoglycaemic agent JTT‐608: direct enhancement of Ca2+ efficacy and increase of Ca2+ influx by phosphodiesterase inhibition
E. Mukai
,
H. Ishida
,
+9 authors
Y. Seino
British Journal of Pharmacology
2000
Corpus ID: 23173420
We examined the effects of the novel hypoglycaemic agent JTT‐608 [trans‐4‐(4‐methylcyclohexyl)‐4‐oxobutyric acid] on insulin…
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1999
1999
JTT‐608 restores impaired early insulin secretion in diabetic Goto‐Kakizaki rats
T. Ohta
,
N. Furukawa
,
G. Komuro
,
F. Yonemori
,
K. Wakitani
British Journal of Pharmacology
1999
Corpus ID: 2812694
We investigated the pharmacological effects of a new antidiabetic agent, JTT‐608, in comparison with the sulphonylurea…
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1999
1999
JTT-608 controls blood glucose by enhancement of glucose-stimulated insulin secretion in normal and diabetes mellitus rats.
T. Ohta
,
N. Furukawa
,
F. Yonemori
,
K. Wakitani
European Journal of Pharmacology
1999
Corpus ID: 28761471
1999
1999
Glucose-dependent insulinotropic effects of JTT-608, a novel antidiabetic compound.
N. Furukawa
,
T. Ohta
,
T. Noguchi
,
F. Yonemori
,
K. Wakitani
European Journal of Pharmacology
1999
Corpus ID: 24281323
1998
1998
4-(trans-4-Methylcyclohexyl)-4-oxobutyric acid (JTT-608). A new class of antidiabetic agent.
H. Shinkai
,
H. Ozeki
,
T. Motomura
,
T. Ohta
,
N. Furukawa
,
I. Uchida
Journal of Medicinal Chemistry
1998
Corpus ID: 6998489
During an investigation of drugs for improving the beta-cell response to glucose, we found that 4-cyclohexyl-4-oxobutyric acid…
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