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JTE 522

Known as: JTE-522 
National Institutes of Health

Papers overview

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2010
2010
Enhancement of the Sensitivity of Renal Cell Carcinoma Cells to Fas-Mediated Cytotoxicity and Apoptosis by the Selective Cyclooxygenase-2 Inhibitor JTE-522
Background: Cyclooxygenase-2 (COX-2) is a key enzyme involved in the production of prostaglandins and its inhibitors have been… 
2007
2007
Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells.
Selective cyclooxygenase-2 (COX-2) inhibitors have been demonstrated to inhibit the proliferation of a variety of cancer cells… 
2005
2005
Suppression of Adjuvant‐Induced Arthritic Bone Destruction by Cyclooxygenase‐2 Selective Agents With and Without Inhibitory Potency Against Carbonic Anhydrase II
In vitro assays revealed that COX‐2 inhibitors with CA II inhibitory potency suppressed both differentiation and activity of… 
2004
2004
Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells.
2004
2004
Cyclooxygenase-2 gene induction causes CDDP resistance in colon cancer cell line, HCT-15.
Drug resistance to cisplatin (CDDP) would represent a major obstacle for cancer therapy. The adenosine triphosphate (ATP) binding… 
2004
2004
JTE‐522, a selective COX‐2 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization: A vascular cast model study
The lung is a frequent site of metastasis from colorectal cancer, but angiogenesis of lung metastases has not been clarified… 
2003
2003
Combination chemotherapy with JTE-522, a novel selective cyclooxygenase-2 inhibitor, and cisplatin against gastric cancer cell lines in vitro and in vivo.
COX-2 over-expression occurs in various cancers, but the role of COX-2 in cancer progression remains to be elucidated. We… 
Highly Cited
2002
Highly Cited
2002
Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents.
This study reports that a selective COX-2 inhibitor JTE-522inhibits both in vitro and in vivo growth of human lung cancer cells… 
2002
2002
JTE-522, a selective COX-2 inhibitor, inhibits cell proliferation and induces apoptosis in RL95-2 cells.
AIM To investigate whether JTE-522 [4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide], a selective COX-2 inhibitor… 
2000
2000
Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines.
An increased expression of cyclooxygenase (COX)-2 has been observed in various cancers including gastric cancer. Although… 
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