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JSM10292

 
National Institutes of Health

Papers overview

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2016
2016
Discovery of new selective antagonists of G-protein coupled receptors of therapeutic interest
GPCR are integral membrane receptor proteins that are characterized by heptahelical transmembrane domains connected by… Expand
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2015
2015
New insights into the stereochemical requirements of the bradykinin B2 receptor antagonists binding
Bradykinin (BK) is a member of the kinin family, released in response to inflammation, trauma, burns, shock, allergy and some… Expand
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2015
2015
of Computer-Aided Molecular Design NEW INSIGHTS INTO THE STEREOCHEMICAL REQUIREMENTS OF THE BRADYKININ B 2 RECEPTOR ANTAGONISTS
Abstract: Bradykinin (BK) is a member of the kinin family, released in response to inflammation, trauma, burns, shock, allergy… Expand
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2012
2012
Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist.
BACKGROUND AND PURPOSE A (3) H-labelled derivative of the novel small-molecule bradykinin (BK) B(2) receptor antagonist JSM10292… Expand
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2011
2011
Helix 8 Plays a Crucial Role in Bradykinin B2 Receptor Trafficking and Signaling
Upon activation the human bradykinin B2 receptor (B2R) acts as guanine nucleotide exchange factor for the G proteins Gq/11 and Gi… Expand
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2009
2009
Novel small molecule bradykinin B2 receptor antagonists.
Blockade of the bradykinin B(2) receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many… Expand
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