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JSM10292

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2015
0120092015

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2015
2015
of Computer-Aided Molecular Design NEW INSIGHTS INTO THE STEREOCHEMICAL REQUIREMENTS OF THE BRADYKININ B 2 RECEPTOR ANTAGONISTS
Abstract: Bradykinin (BK) is a member of the kinin family, released in response to inflammation, trauma, burns, shock, allergy… (More)
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2012
2012
Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist.
BACKGROUND AND PURPOSE A (3) H-labelled derivative of the novel small-molecule bradykinin (BK) B(2) receptor antagonist JSM10292… (More)
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2011
2011
Helix 8 plays a crucial role in bradykinin B(2) receptor trafficking and signaling.
Upon activation the human bradykinin B(2) receptor (B(2)R) acts as guanine nucleotide exchange factor for the G proteins G(q/11… (More)
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2009
2009
Novel small molecule bradykinin B2 receptor antagonists.
Blockade of the bradykinin B(2) receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many… (More)
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