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JSM10292

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Discovery of new selective antagonists of G-protein coupled receptors of therapeutic interest
GPCR are integral membrane receptor proteins that are characterized by heptahelical transmembrane domains connected by… 
2015
2015
New insights into the stereochemical requirements of the bradykinin B2 receptor antagonists binding
Bradykinin (BK) is a member of the kinin family, released in response to inflammation, trauma, burns, shock, allergy and some… 
2015
2015
of Computer-Aided Molecular Design NEW INSIGHTS INTO THE STEREOCHEMICAL REQUIREMENTS OF THE BRADYKININ B 2 RECEPTOR ANTAGONISTS
Abstract: Bradykinin (BK) is a member of the kinin family, released in response to inflammation, trauma, burns, shock, allergy… 
2012
2012
Binding characteristics of [3H]‐JSM10292: a new cell membrane‐permeant non‐peptide bradykinin B2 receptor antagonist
BACKGROUND AND PURPOSE A 3H‐labelled derivative of the novel small‐molecule bradykinin (BK) B2 receptor antagonist JSM10292 was… 
2011
2011
Helix 8 Plays a Crucial Role in Bradykinin B2 Receptor Trafficking and Signaling
Upon activation the human bradykinin B2 receptor (B2R) acts as guanine nucleotide exchange factor for the G proteins Gq/11 and Gi… 
2009
2009
Novel small molecule bradykinin B2 receptor antagonists.
Blockade of the bradykinin B(2) receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many… 
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