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JPH203

National Institutes of Health

Papers overview

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2019
2019
MP51-04 AN L-TYPE AMINO ACID TRANSPORTER 1 INHIBITOR: JPH203 SUPPRESSES BLADDER CANCER GROWTH AND INVASION VIA IGFBP-5
INTRODUCTION AND OBJECTIVES: Cancer cells take up massive amounts of amino acids for survival. L-type amino acid transporter 1… 
2018
2018
First-in-human phaseIstudy of JPH203 in patients with advanced solid tumors.
419Background: Uptake of amino acids is essential for cancer growth. L-type amino acid transporter-1 (LAT-1) is overexpressed in… 
2018
2018
Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line
The anti-epileptic drug pregabalin crosses the blood-brain barrier (BBB) in spite of its low lipophilicity. This study was… 
2017
2017
JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells
Most normal cells express L-type amino acid transporter 2 (LAT2). However, L-type amino acid transporter 1 (LAT1) is highly… 
2015
2015
Abstract 5286: Expression of cancer type amino acid transporter LAT1 is a prognosis prediction factor in breast carcinoma: comparison between triple-negative and non-triple-negative types
Purpose: Amino acid transporters play important roles in cell survival and proliferation. L-Type amino acid transporter 1 (LAT1… 
2014
2014
JPH 203 , an L-Type Amino Acid Transporter 1 – Selective Compound , Induces Apoptosis of YD-38 Human Oral Cancer Cells
Compared to most normal cells that express L-type amino acid transporter 2, L-type amino acid transporter 1 is highly expressed… 
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