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JNJ-38877605

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
C-met inhibition blocks bone metastasis development induced by renal cancer stem cells
Cancer stem cells (CSCs) are key players in bone metastasis. In some renal tumors CSCs overexpress the HGF receptor c-MET… 
2016
2016
Synthesis and biological evaluation of new [1,2,4]triazolo[4,3-a]pyridine derivatives as potential c-Met inhibitors.
2014
2014
Abstract 3726: Inhibition of MET overcomes invasive resistance to Bevacizumab and prolongs survival in orthotopic mouse models of glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most malignant brain tumor. Despite recent therapeutic improvements, the median overall… 
2013
2013
Abstract C25: The use of a patient derived tumor xenograft collection to assess different Met and HGF detection methods and their predictive values for therapy response.
Aims: Met inhibitors are targeted drugs which hold promise for the treatment of tumors with HGF/Met pathway activation. To… 
2011
2011
Cancer Therapy : Preclinical Genetic and Expression Analysis of MET , MACC 1 , and HGF in Metastatic Colorectal Cancer : Response to Met Inhibition in Patient Xenografts and Pathologic Correlations
Purpose: We determined the gene copy numbers for MET, for its transcriptional activator MACC1 and for its ligand hepatocyte… 
2011
2011
Abstract 3607: MET inhibitor sensitivity and resistance
MET, the receptor for HGF regulates proliferation, migration and metastasis of tumor cells. However, similar to EGFR-targeted… 
2008
2008
JNJ-38877605: a selective Met kinase inhibitor inducing regression of Met-driven tumor models.
4837 The Met receptor tyrosine kinase and its ligand, hepatocytegrowth factor (HGF), have been implicated in the developmentand… 
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