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ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as nucleation-promoting factors for the… Expand Aims/hypothesisMetabolomics has provided new insight into diabetes risk assessment. In this study we characterised the human… Expand Autophagy is a catabolic process whereby cytosolic components and organelles are degraded to recycle key cellular materials. It… Expand Nucleation-promoting factors (NPFs) control the spatio-temporal activity of Arp2/3 complex in cells]. Thus, WASP and the WAVE… Expand Junction-mediating and regulatory protein (JMY) was originally identified as a transcriptional co-factor in the p53-response to… Expand JMY is a transcriptional co-factor of p53. Latest work has revealed that JMY is also an actin nucleation factor that regulates… Expand Arp2/3 complex mediates the nucleation of actin filaments in multiple subcellular processes, and is activated by nucleation… Expand Many cellular structures are assembled from networks of actin filaments, and the architecture of these networks depends on the… Expand Despite its obvious importance in tumorigenesis, little information is available on the mechanisms that integrate cell motility… Expand We define here a new mechanism through which Mdm2 (mouse double minute 2) regulates p53 activity, by targeting the p53… Expand