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JM 118

Known as: JM-118, JM118 
National Institutes of Health

Papers overview

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2013
2013
Can Satraplatin be hydrated before the reduction process occurs? The DFT computational study
AbstractHydration reactions of two anticancer Pt(IV) complexes JM149 and JM216 (Satraplatin) were studied computationally… 
2008
2008
COMPARATIVE PROTEIN BINDING, STABILITY AND DEGRADATION OF SATRAPLATIN, JM118 AND CISPLATIN IN HUMAN PLASMA IN VITRO
1 Satraplatin is an investigational orally administered platinum‐based antitumour drug. The present study compared the plasma… 
2008
2008
Preparation, characterization and in vitro anticancer activity of platinum(II) complexes with N-Cyclohexyl-1,3-propanediamine as the carrier.
New JM118 (active form of satraplatin) analogues with N-cyclohexyl-1,3-propanediamine (N-chpda) as the carrier, cis-[Pt(N-chpda… 
Highly Cited
2007
Highly Cited
2007
Preclinical antitumor activity of the oral platinum analog satraplatin
PurposeSatraplatin is an orally available platinum analog. The purpose of this study was to better characterize satraplatin’s… 
2006
2006
Satraplatin, an oral platinum analog, is active and synergistic with paclitaxel and docetaxel in prostate carcinoma models.
14620 Background: Satraplatin is a novel oral platinum analog with potent cytotoxic and antitumor activity in preclinical models… 
2005
2005
The effect of the copper transporters ATP7A and ATP7B on the cytotoxicity and cellular pharmacology of JM-118
4110 Satraplatin is the first orally available platinum chemotherapeutic drug. This drug is of interest in that it has potent in… 
2005
2005
Antiproliferative combination therapy with satraplatin or JM118 and docetaxel
1996
1996
Novel trans platinum complexes: comparative in vitro and in vivo activity against platinum-sensitive and resistant murine tumours.
Two pairs of cis/trans platinum complexes, JM118 (cis-ammine(cyclohexylamine) dichloro platinum(II)) and its trans counterpart… 
Highly Cited
1995
Highly Cited
1995
Transport of cisplatin and bis-acetato-ammine-dichlorocyclohexylamine Platinum(IV) (JM216) in human ovarian carcinoma cell lines: identification of a plasma membrane protein associated with cisplatin…
The mechanisms by which cis-diamminedichloroplatinum(II) (cisplatin) is transported across the plasma membrane (i.e., passive… 
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