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JG 365

Known as: JG-365 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Oligopeptides

Papers overview

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2007
2007
Insights from atomic-resolution X-ray structures of chemically synthesized HIV-1 protease in complex with inhibitors.
The human immunodeficiency virus 1 (HIV-1) protease (PR) is an aspartyl protease essential for HIV-1 viral infectivity. HIV-1 PR… Expand
2004
2004
X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor ( AIDS / retrovirus / diastereomer…
The structure of a crystal complex of the chemically synthesized protease of human immunodeficiency virus 1 with a heptapeptide… Expand
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1999
1999
[Mechanism of action of aspartic proteases. III. Conformational characteristics of HIV-1 protease inhibitor JG-365].
A set of conformations was shown to be characteristic of the free-state spatial structure of substrate-like inhibitor JG-365 for… Expand
1996
1996
Empirical free energy calculations of human immunodeficiency virus type 1 protease crystallographic complexes. II. Knowledge-based ligand-protein interaction potentials applied to thermodynamic…
Empirical free energy calculations of HIV-1 protease crystallographic complexes based on the developed knowledge-based ligand… Expand
Highly Cited
1993
Highly Cited
1993
Catalytic contribution of flap-substrate hydrogen bonds in "HIV-1 protease" explored by chemical synthesis.
  • M. Baca, S. Kent
  • Proceedings of the National Academy of Sciences…
  • 1993
    • Corpus ID: 1481468
An analogue of "HIV-1 protease" was designed in which the ability to donate important water-mediated hydrogen bonds to substrate… Expand
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1992
1992
New hydroxyethylamine HIV protease inhibitors that suppress viral replication.
The synthesis of analogues of AcSerLeuAsn[Phe-HEA-Pro]IleValOMe (1, JG-365; where HEA stands for the hydroxyethylamine unit 2), a… Expand
Highly Cited
1990
Highly Cited
1990
X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.
The structure of a crystal complex of the chemically synthesized protease of human immunodeficiency virus 1 with a heptapeptide… Expand
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