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JB93182

National Institutes of Health

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2005
2005
Scaffold hopping with molecular field points: identification of a cholecystokinin-2 (CCK2) receptor pharmacophore and its use in the design of a prototypical series of pyrrole- and imidazole-based…
A new molecular modeling approach has been used to derive a pharmacophore of the potent and selective cholecystokinin-2 (CCK(2… 
2005
2005
Pharmacological analysis of CCK2 receptors up-regulated using engineered transcription factors
2005
2005
Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists.
The systematic optimization of the structure of a novel 2,4,5-trisubstituted imidazole-based cholecystokinin-2 (CCK(2)) receptor… 
2002
2002
Pharmacological characterization of cholecystokinin receptors mediating contraction of human gallbladder and ascending colon
Cholecystokinin (CCK) produces contractions of gallbladder and colon in a number of different species. Although the effects of… 
2002
2002
Pharmacological analysis of CCK(2) receptor ligands using COS-7 and SK-N-MC cells, expressing the human CCK(2) receptor.
A series of CCK(2) receptor ligands were analysed with respect to their interaction with binding sites in the membranes of COS-7… 
2000
2000
2,7-Dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine as a new template for the design of CCK(2) receptor antagonists.
A novel series of nonpeptide CCK(2) receptor antagonists has been prepared, in which 2,7-dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h… 
Review
1999
Review
1999
CCK2 receptor antagonists: pharmacological tools to study the gastrin–ECL cell-parietal cell axis
Gastrin-recognizing CCK2 receptors are expressed in parietal cells and in so-called ECL cells in the acid-producing part of the… 
1999
1999
Analysis of the behaviour of selected CCKB/gastrin receptor antagonists in radioligand binding assays performed in mouse and rat cerebral cortex
The previously described complex behaviour of the CCKB/gastrin receptor antagonist, L‐365,260, in radioligand binding assays… 
1997
1997
Evaluation of three novel cholecystokinin-B/gastrin receptor antagonists: a study of their effects on rat stomach enterochromaffin-like cell activity.
Gastrin stimulates rat stomach enterochromaffin-like (ECL) cells via activation of cholecystokinin-B/gastrin receptors. The… 
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