JB93182

A new molecular modeling approach has been used to derive a pharmacophore of the potent and selective cholecystokinin-2 (CCK(2… (More)

The systematic optimization of the structure of a novel 2,4,5-trisubstituted imidazole-based cholecystokinin-2 (CCK(2)) receptor… (More)

Designed zinc finger proteins (ZFPs) regulate expression of target genes when coupled to activator or repressor domains… (More)

Cholecystokinin (CCK) produces contractions of gallbladder and colon in a number of different species. Although the effects of… (More)

A series of CCK(2) receptor ligands were analysed with respect to their interaction with binding sites in the membranes of COS-7… (More)

A novel series of nonpeptide CCK(2) receptor antagonists has been prepared, in which 2,7-dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h… (More)

1. The previously described complex behaviour of the CCKB/gastrin receptor antagonist, L-365,260, in radioligand binding assays… (More)

Gastrin-recognizing CCK2 receptors are expressed in parietal cells and in so-called ECL cells in the acid-producing part of the… (More)

Gastrin stimulates rat stomach enterochromaffin-like (ECL) cells via activation of cholecystokinin-B/gastrin receptors. The… (More)