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JAK2 NP_004963.1:p.Y931C

Known as: JAK2 Y931C, Janus Kinase 2 Y931C, Tyrosine-Protein Kinase JAK2 Y931C 
A change in the amino acid residue at position 931 in the tyrosine-protein kinase JAK2 protein where tyrosine has been replaced by cysteine.
National Institutes of Health

Related topics

Related topics

2 relations
JAK2 Gene MutationJAK2 NM_004972.3:c.2792A>G

Papers overview

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2016
2016
In Vitro Modeling of Ph-like ALL Fusions Identifies Novel Kinase-Domain Mutations As Mode of TKI-Resistance - Implications for Targeted Therapy
Introduction Treatment-resistant acute lymphoblastic leukemia (ALL) remains a significant clinical issue. Recently, genomic… 
2015
2015
Abstract A23: Type II JAK2 inhibitor NVP-CHZ868 has potent activity in JAK2-dependent B-cell acute lymphoblastic leukemias (B-ALLs) in vivo.
Approximately 10% of B-ALLs harbor CRLF2 rearrangements and have a poor prognosis. Although these leukemias are addicted to JAK2… 
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