JAK-STAT cascade

Known as: JAK-STAT signal transduction 
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2016
024619942016

Papers overview

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2010
2010
Galectin-3, a β-galactoside-binding lectin, has been proposed to have multifaceted functions in various pathophysiological… (More)
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2010
Highly Cited
2010
Flaviviruses transmitted by arthropods represent a tremendous disease burden for humans, causing millions of infections annually… (More)
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2008
Highly Cited
2008
We report that TG101348, a selective small-molecule inhibitor of JAK2 with an in vitro IC50 of approximately 3 nM, shows… (More)
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2007
2007
An acquired autoactivating mutation with a V617F amino-acid substitution in the JAK2 tyrosine kinase is frequently found in BCR… (More)
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2006
Highly Cited
2006
BACKGROUND The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis… (More)
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2001
2001
Leptin is an adipocyte-secreted hormone that centrally regulates weight control. However, the leptin receptor is expressed not… (More)
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2001
2001
Chronic renal failure (CRF) is associated with resistance to the growth-promoting and anabolic actions of growth hormone (GH). In… (More)
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2000
2000
TSH is an important physiological regulator of growth and function in thyroid gland. The mechanism of action of TSH depends on… (More)
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1996
Highly Cited
1996
An important component of cytokine regulation of cell growth and differentiation is rapid transcriptional activation of genes by… (More)
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1995
Highly Cited
1995
c-Mpl, a member of the hematopoietic cytokine receptor family, is the receptor for thrombopoietin. To investigate signal… (More)
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