FAQ

JAK-STAT cascade

Known as: JAK-STAT signal transduction 
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2016
024619942016

Papers overview

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2010
2010
Galectin-3 exerts cytokine-like regulatory actions through the JAK-STAT pathway.
Galectin-3, a β-galactoside-binding lectin, has been proposed to have multifaceted functions in various pathophysiological… (More)
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Highly Cited
2010
Highly Cited
2010
The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling.
Flaviviruses transmitted by arthropods represent a tremendous disease burden for humans, causing millions of infections annually… (More)
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Highly Cited
2008
Highly Cited
2008
Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.
We report that TG101348, a selective small-molecule inhibitor of JAK2 with an in vitro IC50 of approximately 3 nM, shows… (More)
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2007
2007
Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders
An acquired autoactivating mutation with a V617F amino-acid substitution in the JAK2 tyrosine kinase is frequently found in BCR… (More)
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Highly Cited
2006
Highly Cited
2006
MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia
BACKGROUND The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis… (More)
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2001
2001
Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway.
Leptin is an adipocyte-secreted hormone that centrally regulates weight control. However, the leptin receptor is expressed not… (More)
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2001
2001
Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia.
Chronic renal failure (CRF) is associated with resistance to the growth-promoting and anabolic actions of growth hormone (GH). In… (More)
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2000
2000
Involvement of JAK/STAT (Janus kinase/signal transducer and activator of transcription) in the thyrotropin signaling pathway.
TSH is an important physiological regulator of growth and function in thyroid gland. The mechanism of action of TSH depends on… (More)
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Highly Cited
1996
Highly Cited
1996
Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.
An important component of cytokine regulation of cell growth and differentiation is rapid transcriptional activation of genes by… (More)
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Highly Cited
1995
Highly Cited
1995
Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation.
c-Mpl, a member of the hematopoietic cytokine receptor family, is the receptor for thrombopoietin. To investigate signal… (More)
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