Iodide Transport Defect
National Institutes of Health
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Background: Iodide transport defect (ITD) is a dyshormonogenetic congenital hypothyroidism caused by sodium/iodide symporter (NIS…
Iodide is an irreplaceable component of thyroid hormones; therefore, a key requirement for thyroid hormone synthesis is that…
CONTEXT
Iodide transport defect (ITD) is an autosomal recessive disorder caused by impaired Na(+)/I(-) symporter (NIS)-mediated…
BACKGROUND
Iodide transport defect (ITD) is an infrequent condition associated with congenital dyshormonogenetic goiter due to…
Loss-of-function mutations of the PAX8 gene are considered to mainly cause congenital hypothyroidism (CH) due to thyroid…
CONTEXT
Iodide transport defect (ITD) is an autosomal recessive disorder resulting in varying degrees of congenital…
The Na+/I- symporter (NIS) is a key plasma membrane glycoprotein that mediates active iodide (I-) transport in the thyroid and…
objective Iodide transport defect (ITD) is a rare disorder characterised by an inability of the thyroid to maintain an iodide…
Iodide transport defect (ITD) is a rare disorder causing congenital hypothyroidism. We previously reported that homozygous T354P…