FAQ

International Scale for BCR-ABL1 Measurement

Known as: IS, International Scale, International Scale for Quantitative BCR-ABL1 Result Reporting 
A scale established in 2005 to standardize quantitative BCR-ABL1 measurements across tests and laboratories, so as to facilitate interlaboratory… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1965-2018
05101519652018

Papers overview

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2016
2016
Development and evaluation of a secondary reference panel for BCR-ABL1 quantification on the International Scale
Molecular monitoring of chronic myeloid leukemia patients using robust BCR-ABL1 tests standardized to the International Scale (IS… (More)
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Highly Cited
2014
Highly Cited
2014
Early molecular response predicts outcomes in patients with chronic myeloid leukemia in chronic phase treated with frontline nilotinib or imatinib.
We explored the impact of early molecular response (EMR; BCR-ABL ≤10% on the international scale [BCR-ABL(IS)] at 3 or 6 months… (More)
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Highly Cited
2014
Highly Cited
2014
Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML…
PURPOSE Deep molecular response (MR(4.5)) defines a subgroup of patients with chronic myeloid leukemia (CML) who may stay in… (More)
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2013
2013
Establishment and validation of analytical reference panels for the standardization of quantitative BCR-ABL1 measurements on the international scale.
BACKGROUND Current guidelines for managing Philadelphia-positive chronic myeloid leukemia include monitoring the expression of… (More)
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2013
2013
Chronic Myelogenous Leukemia, Version 1.2014.
The 2014 NCCN Clinical Practice Guidelines in Oncology for Chronic Myelogenous Leukemia recommend quantitative reverse… (More)
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Highly Cited
2012
Highly Cited
2012
Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up
Evaluating Nilotinib Efficacy and Safety in Clinical Trials Newly Diagnosed Patients compares nilotinib and imatinib in patients… (More)
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2011
2011
Cartridge-based automated BCR-ABL1 mRNA quantification: solving the issues of standardization, at what cost?
BACKGROUND Molecular monitoring of chronic myeloid leukemia patients treated with tyrosine kinase inhibitors is essential for… (More)
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Highly Cited
2010
Highly Cited
2010
Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571…
This study examines the prognostic significance of early molecular response using an expanded dataset in chronic myeloid leukemia… (More)
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Highly Cited
2008
Highly Cited
2008
Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates…
An international basis for comparison of BCR-ABL mRNA levels is required for the common interpretation of data derived from… (More)
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2003
2003
[Criteria validation of the Roland Morris questionnaire. A Danish translation of the international scale for the assessment of functional level in patients with low back pain and sciatica].
INTRODUCTION The main concern of patients with low back pain is the functional limitation which the symptoms cause. Therefore it… (More)
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