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Inducible CD4+CD25+ Regulatory T Cells

Known as: iTregs 
Inducible regulatory T-lymphocytes that express CD4, CD25 (the alpha chain of the interleukin 2 receptor) and forkhead box P3 (FOXP3), with potential… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Regulatory T cells in multiple sclerosis and myasthenia gravis
Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system primarily mediated by T lymphocytes with… 
Highly Cited
2015
Highly Cited
2015
IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1
Foxp3+ regulatory T cells (Tregs) play essential roles in maintaining the immune balance. Although the majority of Tregs are… 
Review
2012
Review
2012
TGF-β: the sword, the wand, and the shield of FOXP3(+) regulatory T cells.
Since its rediscovery in the mid-1990s, FOXP3(+) regulatory T cells (Tregs) have climbed the rank to become commander-in-chief of… 
Highly Cited
2012
Highly Cited
2012
Modulation and Recruitment of Inducible Regulatory T Cells by First Trimester Trophoblast Cells
Citation Ramhorst R, Fraccaroli L, Aldo P, Alvero AB, Cardenas I, Leirós CP, Mor G. Modulation and recruitment of inducible… 
Highly Cited
2011
Highly Cited
2011
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
CD4+ T helper cell differentiation is essential for mounting robust immune responses without compromising unresponsiveness toward… 
Highly Cited
2011
Highly Cited
2011
Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling.
Multiple pathways converge to result in the overexpression of T(h)17 cells in the absence of either vitamin D or the vitamin D… 
Highly Cited
2011
Highly Cited
2011
Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors.
Glioblastoma multiforme (GBM) is a highly malignant brain tumor with an average survival time of 15 months. Previously, we and… 
Highly Cited
2010
Highly Cited
2010
Characterization of Protective Human CD4+CD25+ FOXP3+ Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid
Background Protective CD4+CD25+ regulatory T cells bearing the Forkhead Foxp3 transcription factor can now be divided into three… 
2010
2010
The Induced Regulatory T Cell Level, Defined as the Proportion of IL-10+Foxp3+ Cells among CD25+CD4+ Leukocytes, Is a Potential Therapeutic Biomarker for Sublingual Immunotherapy: A Preliminary…
Background:Japanese cedar (Cryptomeria japonica) pollinosis is one of the most prevalent allergies in Japan. Recently, two… 
Review
2007
Review
2007
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation.
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