Imipenem and Cilastatin Sodium

Known as: Imipenem-Cilastatin Sodium, imipenem-cilastatin, sodium salt, Imipenem/Cilastatin Sodium 
A parenteral antibiotic preparation containing imipenem and cilastatin sodium with bactericidal activity. Imipenem, a broad spectrum beta-lactam… (More)
National Institutes of Health

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Cilastatin / Imipenem

Papers overview

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Highly Cited
2013
Highly Cited
2013
Randomized phase 2 trial to evaluate the clinical efficacy of two high-dosage tigecycline regimens versus imipenem-cilastatin for treatment of hospital-acquired pneumonia.
In a previous phase 3 study, the cure rates that occurred in patients with hospital-acquired pneumonia treated with tigecycline… (More)
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2010
2010
Safety and efficacy of intravenous tigecycline in subjects with secondary bacteremia: pooled results from 8 phase III clinical trials.
BACKGROUND Tigecycline is effective in the treatment of complicated skin/skin-structure infection (cSSSI), complicated… (More)
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Highly Cited
2005
Highly Cited
2005
The efficacy and safety of tigecycline for the treatment of complicated intra-abdominal infections: analysis of pooled clinical trial data.
This pooled analysis includes 2 phase 3, double-blind trials designed to evaluate the safety and efficacy of tigecycline, versus… (More)
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Highly Cited
2003
Highly Cited
2003
Treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP) with intravenous colistin: a comparison with imipenem-susceptible VAP.
We prospectively evaluated the efficacy and toxicity of intravenously administered colistin in 35 episodes of ventilator… (More)
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Highly Cited
2002
Highly Cited
2002
Comparison of ampicillin-sulbactam and imipenem-cilastatin for the treatment of acinetobacter ventilator-associated pneumonia.
Acinetobacter organisms, which are a common cause of ventilator-associated pneumonia (VAP) in some health care centers, are… (More)
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Highly Cited
1998
Highly Cited
1998
Prospective randomized comparison of imipenem-cilastatin and piperacillin-tazobactam in nosocomial pneumonia or peritonitis.
Nosocomial pneumonia and acute peritonitis may be caused by a wide array of pathogens, and combination therapy is often… (More)
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1997
1997
A randomized, double-blind clinical trial comparing cefepime plus metronidazole with imipenem-cilastatin in the treatment of complicated intra-abdominal infections. Cefepime Intra-abdominal Infection…
OBJECTIVE To evaluate the safety and efficacy of cefepime hydrochloride plus metronidazole vs the combination of imipenem and… (More)
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1994
1994
Determination of imipenem and cilastatin sodium in Primaxin by first order derivative ultraviolet spectrophotometry.
A UV-spectrophotometric assay to measure the concentrations of the active drug components (imipenem and cilastatin) or Primaxin… (More)
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Highly Cited
1994
Highly Cited
1994
Treatment of severe pneumonia in hospitalized patients: results of a multicenter, randomized, double-blind trial comparing intravenous ciprofloxacin with imipenem-cilastatin. The Severe Pneumonia…
Intravenously administered ciprofloxacin was compared with imipenem for the treatment of severe pneumonia. In this prospective… (More)
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1985
1985
Pharmacokinetics of imipenem and cilastatin in volunteers.
Imipenem/cilastatin sodium consists of imipenem, a broad-spectrum carbapenem antimicrobial agent, and cilastatin sodium, an… (More)
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