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Ibrolipim
A lipoprotein lipase (LPL) activator with antihyperlipidemic activity. Activation of LDL by ibrolipim lowers plasma triglycerides, with a concomitant…
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National Institutes of Health
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NO 1886
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2012
2012
Effect of Ibrolipim on Human Umbilical Vein Endothelial Cells Endothelin-1 and von Willebrand Factor Expression Induced by High Glucose
Xiao-hua Guo
2012
Corpus ID: 87508192
Aim To observe the effect of ibrolipim on the expresstion of endothelin-1(ET-1) and von Willebrand factor(vWF) in cultured human…
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2012
2012
Synthesis of Lipoprotein Lipase Activator Ibrolipim Analogs
Xu Li-feng
2012
Corpus ID: 86922922
Two novel Ibrolipim analogs,diethyl 4-[2-(4-chloro-2-nitrophenyl)hydrazinecarbonyl]benzylphosphonate(5) with 28.1% total yield…
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2010
2010
Effect of ibrolipim on human umbilical vein endothelial cells apoptosis and protein kinase B expression induced by high glucose
He Zhenb
2010
Corpus ID: 88043703
AIM To observe the effect of ibrolipim on the apoptosis and protein kinase B(PKB) phasphorylation in cultured human umbilical…
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2009
2009
Evaluation of induction potency of new drug candidates on CYP1A2 and CYP3A4 using real-time one-step RT-PCR in primary cultures of cryopreserved human hepatocytes.
M. Nishimura
,
S. Narimatsu
,
S. Naito
Drug Metabolism and Pharmacokinetics
2009
Corpus ID: 25711493
SUMMARY This study evaluates the induction potency of new drug candidates on mRNA levels of CYP1A2 and CYP3A4 in primary cultures…
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2008
2008
Effect of ibrolipim on expression of protein kinase-B in myocardium of diabetic miniature pigs
Wei Han-song
2008
Corpus ID: 87757450
AIM To observe the change of protein kinase-B (Akt2) expression in myocardium of diabetic minipigs induced by high-fat/high…
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2007
2007
Reduction of serum triglycerides and free fatty acids with ibrolipim in fat-loaded bama minipigs
Yin Wei-dong
2007
Corpus ID: 87499808
Objective: To evaluate whether ibrolipim(NO-1886),a lipoprotein lipase(LPL) activator,improves the postprandial lipid metabolism…
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2006
2006
Assessment of induction of cytochrome P450 by NO-1886 (ibrolipim), a lipoprotein lipase-promoting agent, in primary cultures of human hepatocytes and in female rat liver.
Y. Morioka
,
M. Nishimura
,
+4 authors
S. Naito
Drug Metabolism and Pharmacokinetics
2006
Corpus ID: 12461642
The mRNA levels of human cytochrome P450 (CYP)2Cs and CYP3As in primary cultures of freshly isolated human hepatocytes were…
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2006
2006
NO-1886 (ibrolipim), a lipoprotein lipase-promoting agent, accelerates the expression of UCP3 messenger RNA and ameliorates obesity in ovariectomized rats.
S. Kano
,
M. Doi
Metabolism: Clinical and Experimental
2006
Corpus ID: 24186455
2006
2006
Tu-P7:199 NO-1886 (IBROLIPIM) reduced plasma triglycerides and free fatty acids in fat-loaded Bama minipigs
H. Hou
,
W. Yin
,
+4 authors
J. X. Xiao
2006
Corpus ID: 70655653
2005
2005
Effects of ibrolipim against atherosclerosis in minipigs
Xi Shou-min
,
Tang Chao-ke
2005
Corpus ID: 88050387
AIM: To explore the application mechanism of NO-1886 (ibrolipim), a synthetic compound, improving dyslipidemia and inhibiting…
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