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ITM2B gene

Known as: BRICD2B, ITM2B, BRICHOS domain containing 2B 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
BRI2 and BRI3 are functionally distinct phosphoproteins.
Review
2015
Review
2015
Lessons from a Rare Familial Dementia: Amyloid and Beyond
Here we review the similarities between a rare inherited disorder, familial British dementia (FBD), and the most common of all… 
2015
2015
Metal ion mediated transition from random coil to β-sheet and aggregation of Bri2-23, a natural inhibitor of Aβ aggregation.
Furin-dependent maturation of the BRI2 protein generates the Bri2-23 fragment that is able to arrest the aggregation of amyloid… 
2012
2012
Memory Deficits of British Dementia Knock-In Mice Are Prevented by Aβ-Precursor Protein Haploinsufficiency
Familial British Dementia (FBD) is caused by an autosomal dominant mutation in the BRI2/ITM2B gene (Vidal et al., 1999). FBDKI… 
2011
2011
BRI2 Protein Regulates β-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE)*♦
Background: The British precursor protein (BRI2) influences amyloid precursor protein metabolism. Results: BRI2 lowers β-amyloid… 
2011
2011
Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.
Two different mutated forms of BRI2 protein are linked with familial British and Danish dementias, which present… 
2011
2011
Increased AβPP processing in familial Danish dementia patients.
An autosomal dominant mutation in the BRI2/ITM2B gene causes Familial Danish Dementia (FDD). We have generated a mouse model of… 
2010
2010
BRI2 homodimerizes with the involvement of intermolecular disulfide bonds
Highly Cited
2005
Highly Cited
2005
LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action.
Highly Cited
2004
Highly Cited
2004
Axonal transport of British and Danish amyloid peptides via secretory vesicles
The ABri and ADan amyloid peptides deposited in familial British and Danish neurodegenerative disorders are generated by… 
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