Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 225,023,441 papers from all fields of science
Search
Sign In
Create Free Account
ITK gene
Known as:
ITK
, TYROSINE KINASE EXPRESSED MAINLY IN T CELLS
, IL2-INDUCIBLE T-CELL KINASE
Expand
This gene is involved in the differentiation and proliferation of T cells.
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
11 relations
Cell Differentiation process
Cell Proliferation
Homo sapiens
IL2-inducible T-cell kinase
Expand
Narrower (1)
ITK wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Course of IL-2-inducible T-cell kinase deficiency in a family: lymphomatoid granulomatosis, lymphoma and allogeneic bone marrow transplantation in one sibling; and death in the other
D. Çağdaş
,
B. Erman
,
+7 authors
I. Tezcan
Bone Marrow Transplantation
2017
Corpus ID: 12952641
Course of IL-2-inducible T-cell kinase deficiency in a family: lymphomatoid granulomatosis, lymphoma and allogeneic bone marrow…
Expand
2014
2014
Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694
Y. Zhong
,
Shuai Dong
,
+14 authors
J. Dubovsky
Journal of Biological Chemistry
2014
Corpus ID: 27149890
Background: ITK and RLK are unique to effector lymphocytes and critical for immune activation. Results: A novel selective…
Expand
2014
2014
ITK tunes IL‐4‐induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell‐independent manner
Weishan Huang
,
Fei Huang
,
Arun K. Kannan
,
Jianfang Hu
,
A. August
Journal of Leukocyte Biology
2014
Corpus ID: 9122456
True memory CD8+ T cells develop post antigenic exposure and can provide life‐long immune protection. More recently, other types…
Expand
2014
2014
Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.
Richard M Pastor
,
J. Burch
,
+12 authors
Z. Pei
Bioorganic & Medicinal Chemistry Letters
2014
Corpus ID: 6111897
2014
2014
Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).
Giancarlo Trani
,
J. Barker
,
+18 authors
Z. Pei
Bioorganic & Medicinal Chemistry Letters
2014
Corpus ID: 23669234
Highly Cited
2006
Highly Cited
2006
Reduced airway hyperresponsiveness and tracheal responses during allergic asthma in mice lacking tyrosine kinase inducible T-cell kinase.
Tanna J Ferrara
,
C. Mueller
,
Nisebita Sahu
,
A. Ben-Jebria
,
A. August
Journal of Allergy and Clinical Immunology
2006
Corpus ID: 2930465
2005
2005
Estimating immunoregulatory gene networks in human herpesvirus type 6-infected T cells.
T. Takaku
,
J. Ohyashiki
,
Yu Zhang
,
K. Ohyashiki
Biochemical and Biophysical Research…
2005
Corpus ID: 28902096
1998
1998
CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.
Philip D. King
,
Ali Sadra
,
Joyce M.C. Teng
,
Gregory M. Bell
,
Bo Dupont
International Immunology
1998
Corpus ID: 5702999
Ligation of the CD2 co-stimulatory receptor on human T lymphocytes induces tyrosine phosphorylation and activation of the Tec…
Expand
Highly Cited
1996
Highly Cited
1996
Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK (*)
S. Gibson
,
A. August
,
D. Branch
,
B. DuPont
,
G. Mills
Journal of Biological Chemistry
1996
Corpus ID: 25108993
Activation of CD28 on T lymphocytes initiates a cascade of intracellular events, which in concert with activation of the T cell…
Expand
Highly Cited
1995
Highly Cited
1995
p56^ and p59^ regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor binding protein GRB-2 and T cell specific kinase ITK: implications for T cell co-stimulation.
M. Raab
1995
Corpus ID: 103499401
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE