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ITK gene

Known as: ITK, TYROSINE KINASE EXPRESSED MAINLY IN T CELLS, IL2-INDUCIBLE T-CELL KINASE 
This gene is involved in the differentiation and proliferation of T cells.
National Institutes of Health

Related topics

Related topics

11 relations
Cell Differentiation processCell ProliferationHomo sapiensIL2-inducible T-cell kinase

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ITK wt Allele

Papers overview

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2017
2017
Course of IL-2-inducible T-cell kinase deficiency in a family: lymphomatoid granulomatosis, lymphoma and allogeneic bone marrow transplantation in one sibling; and death in the other
Course of IL-2-inducible T-cell kinase deficiency in a family: lymphomatoid granulomatosis, lymphoma and allogeneic bone marrow… 
2014
2014
Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694
Background: ITK and RLK are unique to effector lymphocytes and critical for immune activation. Results: A novel selective… 
2014
2014
ITK tunes IL‐4‐induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell‐independent manner
True memory CD8+ T cells develop post antigenic exposure and can provide life‐long immune protection. More recently, other types… 
2014
2014
Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.
2014
2014
Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).
Highly Cited
2006
Highly Cited
2006
Reduced airway hyperresponsiveness and tracheal responses during allergic asthma in mice lacking tyrosine kinase inducible T-cell kinase.
2005
2005
Estimating immunoregulatory gene networks in human herpesvirus type 6-infected T cells.
1998
1998
CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.
Ligation of the CD2 co-stimulatory receptor on human T lymphocytes induces tyrosine phosphorylation and activation of the Tec… 
Highly Cited
1996
Highly Cited
1996
Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK (*)
Activation of CD28 on T lymphocytes initiates a cascade of intracellular events, which in concert with activation of the T cell… 
Highly Cited
1995
Highly Cited
1995
p56^ and p59^ regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor binding protein GRB-2 and T cell specific kinase ITK: implications for T cell co-stimulation.
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