ITK gene

Known as: ITK, TYROSINE KINASE EXPRESSED MAINLY IN T CELLS, IL2-INDUCIBLE T-CELL KINASE 
This gene is involved in the differentiation and proliferation of T cells.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
0102019892017

Papers overview

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Highly Cited
2015
Highly Cited
2015
Monoclonal antibodies can block cellular interactions that negatively regulate T-cell immune responses, such as CD80/CTLA-4 and… (More)
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Highly Cited
2013
Highly Cited
2013
Given its critical role in T-cell signaling, interleukin-2-inducible kinase (ITK) is an appealing therapeutic target that can… (More)
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2010
2010
Peripheral T cell lymphomas (PTCLs) are highly aggressive malignancies with poor prognosis. Their molecular pathogenesis is not… (More)
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Highly Cited
2006
Highly Cited
2006
Among peripheral T-cell lymphomas (PTCL), the heterogeneous category of unspecified PTCL represents the most common subtype… (More)
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Highly Cited
2006
Highly Cited
2006
CD8(+) T cells are commonly divided into naïve CD44(lo)CD122(lo) and "memory phenotype" CD44(hi)CD122(hi) cells. Here we show… (More)
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2004
2004
Chemokines are critical in controlling lymphocyte traffic and migration. The CXC chemokine CXCL12/SDF-1alpha interacts with its… (More)
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Highly Cited
2003
Highly Cited
2003
Allergic asthma patients manifest airway inflammation and some show increases in eosinophils, T(H)2 cells, and cytokines… (More)
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Highly Cited
1997
Highly Cited
1997
The Tec family of tyrosine kinases are involved in signals emanating from cytokine receptors, antigen receptors, and other… (More)
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1995
1995
T-cell activation requires cooperative signals generated by the T-cell antigen receptor zeta-chain complex (TCR zeta-CD3) and the… (More)
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Highly Cited
1994
Highly Cited
1994
The Bmx sequence was identified and cloned during our search for novel tyrosine kinase genes expressed in human bone marrow cells… (More)
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