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ITK gene

Known as: ITK, TYROSINE KINASE EXPRESSED MAINLY IN T CELLS, IL2-INDUCIBLE T-CELL KINASE 
This gene is involved in the differentiation and proliferation of T cells.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Significance Antibodies that block the negative signals between PD1-Ligand on tumor cells and PD-1 on T cells are effective… Expand
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Highly Cited
2013
Highly Cited
2013
Given its critical role in T-cell signaling, interleukin-2-inducible kinase (ITK) is an appealing therapeutic target that can… Expand
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Highly Cited
2013
Highly Cited
2013
Genome-scale transcriptomic profiling of peripheral blood mononuclear cells from patients with idiopathic pulmonary fibrosis… Expand
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Highly Cited
2012
Highly Cited
2012
The purpose of this study was the appraisal of the clinical and functional consequences of germline mutations within the gene for… Expand
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Highly Cited
2012
Highly Cited
2012
ITK-SH3-mediated interactions, both with exogenous ligands and via intermolecular self-association with ITK-SH2, have been shown… Expand
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Review
2007
Review
2007
Recent data from three laboratories have identified the TEC kinases, ITK and RLK, as crucial regulators of CD8+ T-cell… Expand
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Highly Cited
2006
Highly Cited
2006
Among peripheral T-cell lymphomas (PTCL), the heterogeneous category of unspecified PTCL represents the most common subtype… Expand
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Highly Cited
2005
Highly Cited
2005
There is disclosed a coating device for coating bands or ribbons with a coating material in continuous operation. The coating… Expand
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Highly Cited
2003
Highly Cited
2003
Allergic asthma patients manifest airway inflammation and some show increases in eosinophils, TH2 cells, and cytokines, increased… Expand
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Highly Cited
1997
Highly Cited
1997
The Tec family of tyrosine kinases are involved in signals emanating from cytokine receptors, antigen receptors, and other… Expand
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