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ISIS 3082

Known as: ISIS-3082, ISIS3082 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Oligodeoxyribonucleotides

Papers overview

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Highly Cited
2005
Highly Cited
2005
The ICAM‐1 antisense oligonucleotide ISIS‐3082 prevents the development of postoperative ileus in mice
Intestinal manipulation (IM) during abdominal surgery triggers the influx of inflammatory cells, leading to postoperative ileus… Expand
2001
2001
Delivery of cholesteryl-conjugated phosphorothioate oligodeoxynucleotides to Kupffer cells by lactosylated low-density lipoprotein.
The efficacy of antisense oligonucleotides depends on the ability to reach in vivo their target cells. We aim to develop… Expand
Highly Cited
2000
Highly Cited
2000
Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation.
Several studies have shown improved efficacy of cholesteryl-conjugated phosphorothioate antisense oligodeoxynucleotides. To gain… Expand
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Highly Cited
1997
Highly Cited
1997
In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.
Systemically administered phosphorothioate antisense oligodeoxynucleotides can specifically affect the expression of their target… Expand
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Highly Cited
1997
Highly Cited
1997
An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice.
Mice treated p.o. with 5% dextran sodium sulfate develop a mild to moderate colitis characterized by focal areas of inflammation… Expand
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