ISG15 gene

Known as: ISG15, ISG15 ubiquitin-like modifier, UBIQUITIN-LIKE MODIFIER ISG15 
This gene is involved in both protein tagging and cell signaling.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
ISG15 is an interferon (IFN)-α/β-inducible, ubiquitin-like intracellular protein. Its conjugation to various proteins (ISGylation… (More)
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Highly Cited
2010
Highly Cited
2010
ISG15 is an interferon-induced and antiviral ubiquitin-like protein (Ubl). Herc5, the major E3 enzyme for ISG15, mediates the… (More)
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Highly Cited
2008
Highly Cited
2008
RIG-I senses intracellular virus-specific nucleic acid structures and initiates an antiviral response that induces interferon… (More)
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Highly Cited
2007
Highly Cited
2007
Ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15) reversibly conjugate to proteins and mediate important innate… (More)
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Highly Cited
2006
Highly Cited
2006
ISG15 is an interferon (IFN)-alpha/beta-induced ubiquitin-like protein that is conjugated to cellular proteins during innate… (More)
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Highly Cited
2006
Highly Cited
2006
Interferons (IFNs) regulate diverse cellular functions through activation of the Janus kinase-signal transducer and activator of… (More)
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Highly Cited
2006
Highly Cited
2006
The goal of this study was to elucidate the molecular mechanism by which type I IFN inhibits assembly and release of HIV-1… (More)
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Highly Cited
2005
Highly Cited
2005
IFN-alpha/beta plays an essential role in innate immunity against viral and bacterial infection. Among the proteins induced by… (More)
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Highly Cited
2002
Highly Cited
2002
UBP43 shows significant homology to well characterized ubiquitin-specific proteases and previously was shown to hydrolyze… (More)
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Highly Cited
2001
Highly Cited
2001
Of the several hundred proteins induced by interferon (IFN) alpha/beta, the ubiquitin-like ISG15 protein is one of the most… (More)
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