IPI-926

Known as: FIN-5, IP9 Free Base, Smoothened Antagonist IPI-926 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2017
02420092017

Papers overview

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2016
2016
OBJECTIVES In mouse models of pancreatic cancer, IPI-926, an oral Hedgehog inhibitor, increases chemotherapy delivery by… (More)
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2015
2015
The clinical safety and efficacy of IPI-926 was evaluated in 14 patients with myelofibrosis in a phase II study. Patients… (More)
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2014
2014
Hedgehog (Hh) pathway inhibition in cancer has been evaluated in both the ligand-independent and ligand-dependent settings, where… (More)
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2013
2013
PURPOSE To conduct a first-in-human phase I study to determine the dose-limiting toxicities (DLT), characterize the… (More)
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2012
2012
The Sonic Hedgehog (Shh) pathway drives a subset of medulloblastomas, a malignant neuroectodermal brain cancer, and other cancers… (More)
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2012
2012
213 Background: IPI-926 is a novel, natural product-derived small molecule that targets the Hedgehog (Hh) pathway by inhibiting… (More)
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2011
2011
3014 Background: IPI-926 is a novel, selective, oral, natural- product derived small molecule that targets the Hedgehog (Hh… (More)
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2010
2010
Conserved embryonic signaling pathways such as Hedgehog (Hh), Wingless and Notch have been implicated in the pathogenesis of… (More)
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Highly Cited
2009
Highly Cited
2009
Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part because it is insensitive to many… (More)
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2009
2009
Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the… (More)
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