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IPI-926

Known as: FIN-5, IP9 Free Base, Smoothened Antagonist IPI-926 
 
National Institutes of Health

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Highly Cited
2016
Highly Cited
2016
Objectives In mouse models of pancreatic cancer, IPI-926, an oral Hedgehog inhibitor, increases chemotherapy delivery by… Expand
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2016
2016
BACKGROUND This phase 1, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D… Expand
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2015
2015
Abstract The clinical safety and efficacy of IPI-926 was evaluated in 14 patients with myelofibrosis in a phase II study… Expand
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2014
2014
Hedgehog (Hh) pathway inhibition in cancer has been evaluated in both the ligand-independent and ligand-dependent settings, where… Expand
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Highly Cited
2013
Highly Cited
2013
Purpose: To conduct a first-in-human phase I study to determine the dose-limiting toxicities (DLT), characterize the… Expand
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Highly Cited
2012
Highly Cited
2012
The Sonic Hedgehog (Shh) pathway drives a subset of medulloblastomas, a malignant neuroectodermal brain cancer, and other cancers… Expand
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Highly Cited
2012
Highly Cited
2012
The Hedgehog (Hh) signaling pathway regulates tissue patterning during development, including patterning and growth of limbs and… Expand
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Highly Cited
2010
Highly Cited
2010
Conserved embryonic signaling pathways such as Hedgehog (Hh), Wingless and Notch have been implicated in the pathogenesis of… Expand
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Highly Cited
2009
Highly Cited
2009
It's All in the Delivery Pancreatic cancer is almost universally associated with a poor prognosis, in part because the tumors are… Expand
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Highly Cited
2009
Highly Cited
2009
Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the… Expand
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