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INNO-206

National Institutes of Health

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DOXO-EMCH

Papers overview

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2016
2016
Selective delivery of doxorubicin by novel stimuli-sensitive nano-ferritins overcomes tumor refractivity
Human ferritin heavy chain (HFt) has been demonstrated to possess considerable potential for targeted delivery of drugs and… 
2013
2013
Evaluation of combination therapy schedules of doxorubicin and an acid-sensitive albumin-binding prodrug of doxorubicin in the MIA PaCa-2 pancreatic xenograft model.
2012
2012
Phase Ib/II study of INNO-206 (EMCH-doxorubicin) in patients with soft tissue sarcoma.
10036 Background: The safety and preliminary tumor response of a doxorubicin conjugate, INNO-206, was evaluated primarily in… 
2012
2012
Abstract 2756: Combination therapy of doxorubicin and the acid-sensitive albumin-binding prodrug of doxorubicin INNO-206 induces complete regressions in a xenograft pancreatic carcinoma model…
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Combination therapy of macromolecular prodrugs… 
2012
2012
Abstract 2763: Combination therapy of an acid-sensitive albumin-binding prodrug of doxorubicin (INNO-206) and an albumin-binding prodrug of methotrexate (AW054) that is cleaved by cathepsin B and…
Pancreatic cancer is the fourth most common cause of cancer death across the globe. Pancreatic cancer has a poor prognosis. For… 
2012
2012
ESMO: New Agent, Aldoxorubicin (INNO-206), Shows Activity in Soft-Tissue Sarcoma
Results from a phase Ib/II trial presented at the ESMO 2012 Congress found that a tumor-targeting doxorubicin conjugate… 
2011
2011
Anti-Myeloma Effects of the Novel Anthracycline Derivative INNO-206
Abstract 5107 Introduction: Doxorubicin and pegylated liposomal doxorubicin have recently shown efficacy for the treatment of… 
2011
2011
Abstract 2569: Combination of the albumin-binding prodrug of doxorubicin (INNO-206) and doxorubicin produces complete remissions in an ovarian A2780 xenograft model
INNO-206, the (6-maleimidocaproyl)hydrazone of doxorubicin (DOXO-EMCH) is an albumin-binding prodrug of doxorubicin with acid… 
2010
2010
Anti-Myeloma and Anti-Angiogenic Effects of the Novel Anthracycline Derivative INNO-206
Abstract 4065 Doxorubicin and pegylated liposomal doxorubicin have shown efficacy for the treatment of multiple myeloma (MM… 
2007
2007
INNO-206 (6-maleimidocaproyl hydrazone derivative of doxorubicin) shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models
A263 INNO-206 is a novel doxorubicin prodrug that binds circulating serum albumin by utilizing a unique linker that releases… 
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