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High-grade gliomas (HGGs) are the most lethal type of brain tumour in both children and adults. The heterogeneous nature of these… Expand The availability of the anti-HER2 monoclonal antibody, trastuzumab (Herceptin) has transformed the outcome of a subgroup of… Expand 3025 Background: In HER2+ breast cancer, the HER2 protein is cleaved by the metalloproteinase ADAM10 resulting in release of the… Expand Background: In HER2 over-expressing breast cancer cells, the HER2 protein can be cleaved by a metalloproteinase, ADAM10. While… Expand Background: Inhibitors of HER-2/neu and EGF receptors such as trastuzumab, lapatinib, and erlotinib have demonstrated clinical… Expand The ErbB family of receptors is overexpressed in numerous human tumors. Overexpression correlates with poor prognosis and… Expand The HER-2 receptor tyrosine kinase is an important regulator of cell proliferation and survival, and it is a clinically validated… Expand The HER-2 receptor tyrosine kinase is an important regulator of cell proliferation and survival, and it is a clinically validated… Expand