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INCB7839

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
  • M. Villanueva
  • Nature Reviews Drug Discovery
  • 2017
  • Corpus ID: 26867417
High-grade gliomas (HGGs) are the most lethal type of brain tumour in both children and adults. The heterogeneous nature of these… 
2014
2014
The availability of the anti-HER2 monoclonal antibody, trastuzumab (Herceptin) has transformed the outcome of a subgroup of… 
2010
2010
3025 Background: In HER2+ breast cancer, the HER2 protein is cleaved by the metalloproteinase ADAM10 resulting in release of the… 
2009
2009
Background: In HER2 over-expressing breast cancer cells, the HER2 protein can be cleaved by a metalloproteinase, ADAM10. While… 
2009
2009
Background: Inhibitors of HER-2/neu and EGF receptors such as trastuzumab, lapatinib, and erlotinib have demonstrated clinical… 
Highly Cited
2008
Highly Cited
2008
The ErbB family of receptors is overexpressed in numerous human tumors. Overexpression correlates with poor prognosis and… 
Highly Cited
2006
Highly Cited
2006
The HER-2 receptor tyrosine kinase is an important regulator of cell proliferation and survival, and it is a clinically validated… 
2006
2006
The HER-2 receptor tyrosine kinase is an important regulator of cell proliferation and survival, and it is a clinically validated…