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INCB7839

 
National Institutes of Health

Papers overview

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2017
2017
  • M. Villanueva
  • Nature Reviews Drug Discovery
  • 2017
  • Corpus ID: 26867417
High-grade gliomas (HGGs) are the most lethal type of brain tumour in both children and adults. The heterogeneous nature of these… Expand
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2014
2014
The availability of the anti-HER2 monoclonal antibody, trastuzumab (Herceptin) has transformed the outcome of a subgroup of… Expand
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2010
2010
3025 Background: In HER2+ breast cancer, the HER2 protein is cleaved by the metalloproteinase ADAM10 resulting in release of the… Expand
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2009
2009
Background: In HER2 over-expressing breast cancer cells, the HER2 protein can be cleaved by a metalloproteinase, ADAM10. While… Expand
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2009
2009
Background: Inhibitors of HER-2/neu and EGF receptors such as trastuzumab, lapatinib, and erlotinib have demonstrated clinical… Expand
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Highly Cited
2008
Highly Cited
2008
The ErbB family of receptors is overexpressed in numerous human tumors. Overexpression correlates with poor prognosis and… Expand
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2006
2006
The HER-2 receptor tyrosine kinase is an important regulator of cell proliferation and survival, and it is a clinically validated… Expand
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2006
2006
The HER-2 receptor tyrosine kinase is an important regulator of cell proliferation and survival, and it is a clinically validated… Expand
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