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IMT504

National Institutes of Health

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Oligodeoxyribonucleotides

Papers overview

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2019
2019
SAT-172 Continuous, Prolonged Treatment with the Oligonucleotide IMT504 in Diabetic NOD Mice Greatly Improves All Parameters of the Diabetic Condition
Abstract We have shown that the immunomodulatory oligonucleotide IMT504 (IMT) induces a marked recovery of single-dose… 
2018
2018
Long-lasting ameliorating effects of the oligodeoxynucleotide IMT504 on mechanical allodynia and hindpaw edema in rats with chronic hindpaw inflammation
2016
2016
Proposed mechanisms for oligonucleotide IMT504 induced diabetes reversion in a mouse model of immunodependent diabetes.
Type 1 diabetes (T1D) originates from autoimmune β-cell destruction. IMT504 is an immunomodulatory oligonucleotide that increases… 
2014
2014
Non-clinical safety studies of IMT504, a unique non-CpG oligonucleotide.
IMT504 is a non-CpG 24-mer oligodeoxynucleotide (ODN) with immunomodulatory as well as tissue repair activity. IMT504 has been… 
2012
2012
Oligodeoxynucleotide IMT504: lack of effect on immune parameters during islet regeneration in single dose streptozotocin‐induced diabetes
We have shown that oligodeoxynucleotide IMT504 improved blood glucose and islet beta‐cell content in streptozotocin (STZ)‐induced… 
2011
2011
Addition of the immunostimulatory oligonucleotide IMT504 to a seasonal flu vaccine increases hemagglutinin antibody titers in young adult and elder rats, and expands the anti-hemagglutinin antibody…
Flu vaccines are partially protective in infants and elder people. New adjuvants such as immunostimulatory oligonucleotides (ODNs… 
2008
2008
Oligonucleotide IMT504 reduces neuropathic pain after peripheral nerve injury
2007
2007
376 OLIGONUCLEOTIDE IMT504 REDUCES NEUROPATHIC PAIN AFTER PERIPHERAL NERVE INJURY
2006
2006
Oligonucleotide IMT504 induces an immunogenic phenotype and apoptosis in chronic lymphocytic leukemia cells.
Oligonucleotides (ODNs) of the PyNTTTTGT class directly stimulate B lymphocytes and plasmacytoid dendritic cells of the immune… 
2005
2005
PyNTTTTGT prototype oligonucleotide IMT504 is a potent adjuvant for the recombinant hepatitis B vaccine that enhances the Th1 response.
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